1217507-31-7

Basic information

• Product Name: N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pivalamide
• Synonyms: N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pivalamide
• CAS NO: 1217507-31-7
• Molecular Weight: 317.206
• Mol File: 1217507-31-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pivalamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pivalamide(1217507-31-7)
• EPA Substance Registry System: N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pivalamide(1217507-31-7)

Safety Data

• Hazardous Substances Data: 1217507-31-7(Hazardous Substances Data)

Upstream product

• 651-83-2 4-trifluoromethyl-2,3,5,6-tetrafluoroaniline 
• 3282-30-2 pivaloyl chloride 
• 75-98-9 Trimethylacetic acid 

Downstream Products

• 1217507-47-5 benzyl 2-(4,4-dimethyl-5-oxo-1-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pyrrolidin-2-yl)acetate 
• 19036-43-2 aminopivalic acid 
• 1257521-45-1 3,3-dimethyl-1-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pyrrolidine-2,5-dione 

Relevant articles and documents

Palladium(0)/PAr3-catalyzed intermolecular amination of C(sp3)-H bonds: Synthesis of β-amino acids

An intermolecular C(sp3)-H amination using a Pd0/PAr3 catalyst was developed. The reaction begins with oxidative addition of R2N-OBz to a Pd0/PAr3 catalyst and subsequent cleavage of a C(sp3)-H bond by the generated Pd-NR2 intermediate. The catalytic cycle proceeds without the need for external oxidants in a similar manner to the extensively studied palladium(0)-catalyzed C-H arylation reactions. The electron-deficient triarylphosphine ligand is crucial for this C(sp3)-H amination reaction to occur.