121758-27-8Relevant articles and documents
Fe/Cr- and Co/Cr-mediated catalytic asymmetric 2-haloallylations of aldehydes
Kurosu, Michio,Lin, Mei-Huey,Kishi, Yoshito
, p. 12248 - 12249 (2007/10/03)
The first example to couple aldehydes and 3-bromo-2-halopropenes in a catalytic asymmetric manner is reported. The coupling reaction is effected by the use of a chiral sulfonamide-Cr complex (prepared in situ from 1d, CrBr3, Fe(III) or from Co(II), Et3N, and Mn), TMSCl, and 2,6-lutidine. The method reported here is operationally simple and scalable, furnishing 3-halohomoallylic alcohols with a synthetically useful level of enantiomeric excess. Copyright