1217603-26-3 Usage
Description
FMOC-(2R,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOIC ACID is a chemical compound that features an FMOC (9-fluorenylmethyloxycarbonyl) protecting group attached to a 2R,3R-3-amino-2-hydroxy-5-methylhexanoic acid moiety. FMOC-(2R,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOIC ACID is characterized by its ability to provide a chiral center, which is crucial for the synthesis of chiral peptides and related compounds. The FMOC group plays a pivotal role in protecting the amine group on the amino acid, facilitating selective deprotection and coupling reactions during peptide assembly. This makes FMOC-(2R,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOIC ACID an essential chemical tool in the production of diverse peptide-based molecules, particularly in the fields of biochemistry and medicinal chemistry.
Uses
Used in Peptide Synthesis:
FMOC-(2R,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOIC ACID is used as a building block in peptide synthesis for the creation of peptides with specific sequences and properties. FMOC-(2R,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOIC ACID's chiral center allows for the development of peptides with unique biological activities and selectivity.
Used in Biochemistry Research:
In the field of biochemistry, FMOC-(2R,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOIC ACID is utilized for the synthesis of chiral peptides, which are essential for studying enzyme specificity, receptor binding, and other biological interactions.
Used in Medicinal Chemistry:
FMOC-(2R,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOIC ACID is employed in medicinal chemistry for the design and synthesis of peptide-based drugs. FMOC-(2R,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOIC ACID's ability to create chiral peptides aids in the development of therapeutic agents with improved efficacy and selectivity.
Used in Drug Development:
In the pharmaceutical industry, FMOC-(2R,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOIC ACID is used as a key component in the development of new drugs. Its role in peptide synthesis allows for the creation of innovative therapeutic agents with potential applications in various medical conditions.
Used in Chemical Synthesis Education:
FMOC-(2R,3R)-3-AMINO-2-HYDROXY-5-METHYLHEXANOIC ACID is also used as an educational tool in teaching laboratories to demonstrate the principles of peptide synthesis, selective protection, and coupling reactions, providing students with hands-on experience in the synthesis of complex organic molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 1217603-26-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,7,6,0 and 3 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1217603-26:
(9*1)+(8*2)+(7*1)+(6*7)+(5*6)+(4*0)+(3*3)+(2*2)+(1*6)=123
123 % 10 = 3
So 1217603-26-3 is a valid CAS Registry Number.
1217603-26-3Relevant articles and documents
Evaluation of transition-state mimics in a superior BACE1 cleavage sequence as peptide-mimetic BACE1 inhibitors
Hattori, Yasunao,Kobayashi, Kazuya,Deguchi, Ayaka,Nohara, Yukie,Akiyama, Tomomi,Teruya, Kenta,Sanjoh, Akira,Nakagawa, Atsushi,Yamashita, Eiki,Akaji, Kenichi
, p. 5626 - 5640 (2015/11/11)
A superior substrate sequence for BACE1 containing transition-state mimics at the scissile site was evaluated as a protease inhibitor. Hydroxymethylcarbonyl (HMC) and hydroxyethylamine (HEA) isosteres were selected as the transition state mimics, and inco
Chemoenzymatic synthesis of Fmoc-protected (2S,3S)-2-hydroxy-3-amino acids and their application in the synthesis of an α-hydroxylated β-hexapeptide
Tromp, Reynier A.,Van der Hoeven, Michael,Amore, Alessia,Brussee, Johannes,Overhand, Mark,Van der Marel, Gijs A.,Van der Gen, Arne
, p. 1109 - 1112 (2007/10/03)
A chemoenzymatic and stereoselective synthesis of Fmoc-protected (2S,3S)-2-hydroxy-3-amino acids from 2-furaldehyde is described as well as their application, without prior hydroxyl protection, in the solid-phase synthesis of a novel completely α-hydroxylated β-hexapeptide.
