121842-79-3 Usage
Description
TETRANOR-12(S)-HETE is a major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE, a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. It is primarily found in platelets, leukocytes, and to a lesser extent in smooth muscle cells. Although no specific biological function has been determined for TETRANOR-12(S)-HETE, some data suggest it may play a role in controlling the inflammatory response in injured corneas. In certain diseases, such as Zellweger’s Syndrome, peroxisomal abnormalities result in the inability of cells to metabolize 12(S)-HETE, which may contribute to the symptoms of the disease. TETRANOR-12(S)-HETE is available as a research tool for the elucidation of the metabolic fate of its parent compound.
Uses
Used in Pharmaceutical Research:
TETRANOR-12(S)-HETE is used as a research tool for investigating the metabolic fate of its parent compound, 12(S)-HETE, and understanding its role in various biological processes.
Used in Disease Research:
TETRANOR-12(S)-HETE is used in the study of diseases, such as Zellweger’s Syndrome, where peroxisomal abnormalities result in the inability of cells to metabolize 12(S)-HETE, potentially contributing to the symptoms of the disease.
Used in Inflammation and Immunology Research:
Some data indicate that TETRANOR-12(S)-HETE may play a role in controlling the inflammatory response in injured corneas, making it a valuable research tool for studying inflammation and immune responses in ocular conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 121842-79-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,1,8,4 and 2 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 121842-79:
(8*1)+(7*2)+(6*1)+(5*8)+(4*4)+(3*2)+(2*7)+(1*9)=113
113 % 10 = 3
So 121842-79-3 is a valid CAS Registry Number.
121842-79-3Relevant articles and documents
A CONCISE SYNTHESIS OF (R)-HYDROXY-E,Z-DIENE FATTY ACIDS: PREPARATION OF 12(R)-HETE, TETRANOR-12(R)-HETE, AND 13(R)-HODE
Lumin, Sun,Falck, J. R.,Schwartzman, Michal L.
, p. 2315 - 2318 (2007/10/02)
Chiral E-enals derived from functionalized 2-deoxy-D-ribofuranoses by ylide-induced β-elimination were exploited for the synthesis of fatty acid metabolites containing (R)-hydroxy-E,Z-diene subunit.
