1218795-13-1

Basic information

• Product Name: 1-((2-iodophenyl)methyl)-1H-pyrazole
• Synonyms: 1-((2-iodophenyl)methyl)-1H-pyrazole
• CAS NO: 1218795-13-1
• Molecular Weight: 284.099
• Mol File: 1218795-13-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-((2-iodophenyl)methyl)-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((2-iodophenyl)methyl)-1H-pyrazole(1218795-13-1)
• EPA Substance Registry System: 1-((2-iodophenyl)methyl)-1H-pyrazole(1218795-13-1)

Safety Data

• Hazardous Substances Data: 1218795-13-1(Hazardous Substances Data)

Upstream product

• 288-13-1 NH-pyrazole 
• 40400-13-3 2-Iodobenzyl bromide 

Downstream Products

• 10199-67-4 1-benzylpyrazole 
• 23630-48-0 8H-pyrazolo[5,1-a]isoindole 
• 1252590-81-0 C₂₀H₁₆N₄ 

Relevant articles and documents

N-Picolinamides as ligands for Ullmann-type C-N coupling reactions

The use of N-phenyl-2-pyridincarboxamide-1-oxide as a ligand with Cu2O in Ullmann type C-N bond formations between aryl halides and N-heteroaryls in common solvents, such as MeCN, DMF, and DMSO at 82-120 °C has been successfully demonstrated. The ligand is effective when only 4% equiv is used relative to the substrate. The reaction provided the corresponding products in coupling of electron-rich, electron poor, and ortho-substituted aryl halides, including ortho aryl-chlorides, in good to very good yields. N-arylation is selectively preferred at the benzyl position when ortho-halide benzyl bromide is reacted with one equivalent of pyrazole. However, di-N-arylation is achieved in very high yields when 2.5 equiv of pyrazole is used, providing a stoichiometric control over the coupling reaction.