1219438-80-8

Basic information

• Product Name: 3-(2',3',4',6'-tetra-O-benzyl-β-D-glucopyranosyloxy)-1,2-dimethyl-4(1H)-pyridinone
• Synonyms: 3-(2',3',4',6'-tetra-O-benzyl-β-D-glucopyranosyloxy)-1,2-dimethyl-4(1H)-pyridinone
• CAS NO: 1219438-80-8
• Molecular Weight: 661.795
• Mol File: 1219438-80-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(2',3',4',6'-tetra-O-benzyl-β-D-glucopyranosyloxy)-1,2-dimethyl-4(1H)-pyridinone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2',3',4',6'-tetra-O-benzyl-β-D-glucopyranosyloxy)-1,2-dimethyl-4(1H)-pyridinone(1219438-80-8)
• EPA Substance Registry System: 3-(2',3',4',6'-tetra-O-benzyl-β-D-glucopyranosyloxy)-1,2-dimethyl-4(1H)-pyridinone(1219438-80-8)

Safety Data

• Hazardous Substances Data: 1219438-80-8(Hazardous Substances Data)

Upstream product

• 30652-11-0 deferiprone 
• 4291-69-4 2,3,4,6-Tetra-O-benzyl-D-glucopyranose 

Relevant articles and documents

In vitro studies of 3-hydroxy-4-pyridinones and their glycosylated derivatives as potential agents for Alzheimer's disease

Glycosides of 3-hydroxy-4-pyridinones were synthesized and characterized by mass spectrometry, elemental analysis, 1H and 13C NMR spectroscopy, and in one case by X-ray crystallography. The Cu2+ complex of a novel 3-hydroxy-4-pyridinone was synthesized and characterized by IR and X-ray crystallography, showing the ability of these compounds to chelate potentially toxic metal ions. An MTT cytotoxicity assay of a selected glycosylated compound showed a relatively low toxicity of IC50 = 570 ± 90 μM in a human breast cancer cell line. The pyridinone glycosides could be cleaved by a broad specificity beta-glycosidase, Agrobacterium sp.β-glucosidase, and for one compound kcat and Km were determined to be 19.8 s-1 and 1.52 mM, respectively. Trolox Equivalent Antioxidant Capacity (TEAC) values were determined for the free pyridinones, indicating the good antioxidant properties of these compounds. Metal-Aβ1-40 aggregates with zinc and copper were resolubilized by the non-glycosylated pyridinone ligands. The Royal Society of Chemistry 2010.