1219708-35-6

Basic information

• Product Name: C₂₁H₂₈N₂O₁₁S₂
• Synonyms: C₂₁H₂₈N₂O₁₁S₂
• CAS NO: 1219708-35-6
• Molecular Weight: 548.592
• Mol File: 1219708-35-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₈N₂O₁₁S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₈N₂O₁₁S₂(1219708-35-6)
• EPA Substance Registry System: C₂₁H₂₈N₂O₁₁S₂(1219708-35-6)

Safety Data

• Hazardous Substances Data: 1219708-35-6(Hazardous Substances Data)

Upstream product

• 138-37-4 mafenide hydrochloride 
• 6806-56-0 O²,O³,O⁴,O⁶,S-Pentaacetyl-1-thio-β-D-glucopyranose 

Downstream Products

• 1219708-45-8 C₂₁H₂₈N₂O₁₃S₂ 

Relevant articles and documents

Sulfonamide linked neoglycoconjugates-A new class of inhibitors for cancer-associated carbonic anhydrases

The contribution of membrane-bound carbonic anhydrases (CAs) to hypoxic tumor growth and progression in cancer implicates cancer-associated CAs as a promising drug target for oncology. In this paper, we present a new class of sulfonamide-linked neoglycoconjugate that was designed to selectively target and inhibit the extracellular domains of the cancer-relevant CA isozymes. We describe the application of novel, yet straightforward, chemistry toward the synthesis of inhibitors that comprise both S-glycosyl sulfenamides and S-glycosyl sulfonamides. We also present the CA inhibition profile of our new neoglycoconjugates, more specifically a library of 30 compounds (3-32) that were designed to optimize both SAR (structure-activity relationship) and SPR (structure-property relationship) characteristics. We show that our approach produces neutral, water-soluble, and potent inhibitors (Kis in the low nanomolar range) that target cancer-associated CAs.