121980-50-5Relevant articles and documents
The Regioselective Synthesis of Halophenols
Rege, Francis M. G. De,Buchwald, Stephen L.
, p. 4291 - 4296 (1995)
The reactions of borates and borinates with zirconocene complexes of substituted benzynes lead regioselectively to heterodimetallic compounds which were, without isolation, converted to the corresponding halophenols.
Double heteroatom functionalization of arenes using benzyne three-component coupling
Garca-Lpez, Jos-Antonio,etin, Meliha,Greaney, Michael F.
supporting information, p. 2156 - 2159 (2015/02/19)
Arynes participate in three-component coupling reactions with N, S, P, and Se functionalities to yield 1,2-heteroatom-difunctionalized arenes. Using 2-iodophenyl arylsulfonates as benzyne precursors, we could effectively add magnesiated S-, Se-, and N-nucleophilic components to the strained triple bond. In the same pot, addition of electrophilic N, S, or P reagents and a copper(I) catalyst trapped the intermediate aryl Grignard to produce a variety of 1,2- difunctionalized arenes.
HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS
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, (2013/10/22)
The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
