1219818-76-4

Basic information

• Product Name: 4-chloro-2-(3,4-dichlorophenylcarbamoyl)phenyl decylcarbamate
• Synonyms: 4-chloro-2-(3,4-dichlorophenylcarbamoyl)phenyl decylcarbamate
• CAS NO: 1219818-76-4
• Molecular Weight: 499.865
• Mol File: 1219818-76-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-chloro-2-(3,4-dichlorophenylcarbamoyl)phenyl decylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2-(3,4-dichlorophenylcarbamoyl)phenyl decylcarbamate(1219818-76-4)
• EPA Substance Registry System: 4-chloro-2-(3,4-dichlorophenylcarbamoyl)phenyl decylcarbamate(1219818-76-4)

Safety Data

• Hazardous Substances Data: 1219818-76-4(Hazardous Substances Data)

Upstream product

• 95-76-1 m,p-dichloroaniline 
• 321-14-2 5-chloro-2-hydroxybenzoic acid 
• 1191-69-1 decyl isocyanate 
• 642-84-2 3',4',5-trichlorosalicylanilide 

Relevant articles and documents

Acetylcholinesterase-inhibiting activity of salicylanilide N-alkylcarbamates and their molecular docking

A series of twenty-five novel salicylanilide N-alkylcarbamates were investigated as potential acetylcholinesterase inhibitors. The compounds were tested for their ability to inhibit acetylcholinesterase (AChE) from electric eel (Electrophorus electricus L.). Experimental lipophilicity was determined, and the structure-activity relationships are discussed. The mode of binding in the active site of AChE was investigated by molecular docking. All the discussed compounds expressed significantly higher AChE inhibitory activity than rivastigmine and slightly lower than galanthamine. Disubstitution by chlorine in C'(3,4) of the aniline ring and the optimal length of hexyl-undecyl alkyl chains in the carbamate moiety provided the most active AChE inhibitors. Monochlorination in C'(4) exhibited slightly more effective AChE inhibitors than in C'(3). Generally it can be stated that compounds with higher lipophilicity showed higher inhibition, and the activity of the compounds is strongly dependent on the length of the N-alkyl chain.

Salicylanilide carbamates: Antitubercular agents active against multidrug-resistant Mycobacterium tuberculosis strains

A series of 27 salicylanilide-based carbamates was prepared as a part of our ongoing search for new antituberculosis drugs. These compounds exhibited very good in vitro activity against Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium and, in particular, against five multidrug-resistant strains, with MIC values between 0.5-2 μmol/L. Moreover, they displayed moderate toxicity against intestinal cells with the selectivity index being up to 96. Furthermore, acid stability and a half-life of 43 h at pH 7.4 were shown. Thus, these novel salicylanilide derivatives are drug candidates which should be seriously consider for further screening.