122-11-2 Usage
Brand Name(s) in US
Albon, Bactrovet, and generic
Chemical Properties
White Solid
Originator
Madribon,Roche,US,1958
Uses
Different sources of media describe the Uses of 122-11-2 differently. You can refer to the following data:
1. Antibacterial.
2. Antibacterial.This compound is a contaminant of emerging concern (CECs).
Definition
ChEBI: A sulfonamide consisting of pyrimidine having methoxy substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.
Manufacturing Process
1.4 g of 4-phenylsulfonyl-2,6-dimethoxypyrimidine and 4 g of sodium
sulfanilamide (both dried over potassium hydroxide) were very finely ground
and heated in an oil bath for 10 hours at 120°C (inside temperature). The
reaction mixture was taken up in 30 ml of water and treated with 3 ml of 2 N
sodium hydroxide solution. After standing for one hour at 0°C, the turbid
solution was filtered and the filtrate was made alkaline with sodium carbonate.
After again standing for one hour at 0°C, the precipitate was filtered off (1.9 g
of regenerated sulfanilamide) and the filtrate was neutralized with acetic acid,
whereupon crystallization resulted. The isolated crystals of 4-sulfanilamido-
2,6-dimethoxypyrimidine weighed 1.3 g (84% of theory), melting point 190°C
to 196°C.
Therapeutic Function
Antibacterial
Pharmaceutical Applications
2,4-Dimethoxy-6-sulfanilamido-1,3-diazine. A rapidly absorbed
compound with a long half-life (38–40 h) and a high degree of
protein binding (98%). Renal clearance is very slow, and daily
dosage maintains adequate plasma levels.
Safety Profile
Moderately toxic by intraperitoneal, intravenous, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.
Veterinary Drugs and Treatments
Sulfadimethoxine injection and tablets are approved for use in dogs
and cats for respiratory, genitourinary, enteric and soft tissue infections
caused by susceptible organisms. Sulfadimethoxine is used in
the treatment of coccidiosis in dogs although not approved for this
indication.
In horses, sulfadimethoxine injection is approved for the treatment
of respiratory infections caused by Streptococcus equi.
In cattle, the drug is approved for treating shipping fever complex,
calf diphtheria, bacterial pneumonia and foot rot caused by
susceptible organisms.
In poultry, sulfadimethoxine is added to drinking water to treat
coccidiosis, fowl cholera, and infectious coryza.
Check Digit Verification of cas no
The CAS Registry Mumber 122-11-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 2 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 122-11:
(5*1)+(4*2)+(3*2)+(2*1)+(1*1)=22
22 % 10 = 2
So 122-11-2 is a valid CAS Registry Number.
122-11-2Relevant articles and documents
A sulfonamide - 2, 6 - dimethoxy pyrimidine preparation method (by machine translation)
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Paragraph 0027; 0028; 0035; 0036; 0040; 0041; 0045; 0046, (2017/12/05)
The invention relates to a sulfonamide - 2, 6 - dimethoxy pyrimidine of the preparation method, the 4 - amino - 2, 6 - dimethoxy pyrimidine and P-acetyl amino sulfonyl chloride in N, N - dimethyl formamide and the presence of triethylamine, in the 15 - 20 °C reaction under 10 - 14 hours, then post-processed to obtain 4 - P-acetyl amino sulfonamide - 2, 6 - dimethoxy pyrimidine; will be 4 - P-acetyl amino sulfonamide - 2, 6 - dimethoxy pyrimidine in methanol and the mass concentration is 15% -25% of sodium hydroxide solution in the presence of, in 85 - 90 °C reaction 5 - 7 hours, then post-processed to obtain the sulfonamide - 2, 6 - dimethoxy pyrimidine. The invention the synthetic route and the optimization of the process conditions and the like, so that the realization of the kg sulfonamide - 2, 6 - dimethoxy pyrimidine at the time of preparation, sulfonamide - 2, 6 - dimethoxy pyrimidine yield and purity of the still very high, is suitable for industrial production. (by machine translation)
p-NITROBENZENESULFONYL CHLORIDE AS A RAW MATERIAL FOR THE MANUFACTURE OF SULFANILAMIDE PREPARATIONS
Luk'yanov, A. V.,Onoprienko, V. S.,Borodina, K. S.,Zasosov, V. A.,Van'kovich, E. V.,et al.
, p. 640 - 644 (2007/10/02)
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