1220034-97-8 Usage
Description
(4-Benzyl-1-piperazinyl)(4-piperidinyl)methanonehydrochloride is a chemical compound that features a piperazine ring with a benzyl group and a piperidine ring attached to a methanone group. It is widely recognized for its role as a pharmaceutical intermediate, facilitating the synthesis of a range of medications, particularly psychoactive drugs and antipsychotics. The hydrochloride salt form enhances the stability and solubility of the compound, which is advantageous for its application in research and manufacturing processes. (4-Benzyl-1-piperazinyl)(4-piperidinyl)methanonehydrochloride holds promise for the development of innovative medications aimed at treating a variety of neurological and psychiatric disorders within the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
(4-Benzyl-1-piperazinyl)(4-piperidinyl)methanonehydrochloride serves as a crucial pharmaceutical intermediate, utilized in the synthesis of various psychoactive drugs and antipsychotics. Its structural composition allows for the creation of medications that can potentially address a range of neurological and psychiatric disorders.
Used in Research and Development:
In the realm of scientific research, (4-Benzyl-1-piperazinyl)(4-piperidinyl)methanonehydrochloride is employed as a key component in the development of new medications. Its hydrochloride salt form provides the necessary stability and solubility, making it an ideal candidate for experimental procedures and the formulation of novel therapeutic agents.
Used in Medication Synthesis:
(4-Benzyl-1-piperazinyl)(4-piperidinyl)methanonehydrochloride is used as a building block in the synthesis of medications, particularly those intended for the treatment of neurological and psychiatric conditions. Its unique structure allows for the design of drugs that can interact with specific targets in the body, offering potential therapeutic benefits for patients.
Used in Drug Formulation:
(4-Benzyl-1-piperazinyl)(4-piperidinyl)methanonehydrochloride is also used in the formulation of drugs, where its hydrochloride salt form contributes to the compound's ease of handling and incorporation into various pharmaceutical formulations. This enhances the overall process of drug development and manufacturing, ensuring that the final product is both effective and stable for patient use.
Check Digit Verification of cas no
The CAS Registry Mumber 1220034-97-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,0,0,3 and 4 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1220034-97:
(9*1)+(8*2)+(7*2)+(6*0)+(5*0)+(4*3)+(3*4)+(2*9)+(1*7)=88
88 % 10 = 8
So 1220034-97-8 is a valid CAS Registry Number.
1220034-97-8Relevant articles and documents
Synthesis and in vitro biological evaluation of carbonyl group-containing inhibitors of vesicular acetylcholine transporter
Efange, Simon M. N.,Khare, Anil B.,Von Hohenberg, Krystyna,MacH, Robert H.,Parsons, Stanley M.,Tu, Zhude
experimental part, p. 2825 - 2835 (2010/08/05)
To identify selective high-affinity inhibitors of the vesicular acetylcholine transporter (VAChT), we have interposed a carbonyl group between the phenyl and piperidyl groups of the prototypical VAChT ligand vesamicol and its more potent analogues benzovesamicol and 5-aminobenzovesamicol. Of 33 compounds synthesized and tested, 6 display very high affinity for VAChT (K i, 0.25-0.66 nM) and greater than 500-fold selectivity for VAChT over σ1 and σ2 receptors. Twelve compounds have high affinity (Ki, 1.0-10 nM) and good selectivity for VAChT. Furthermore, 3 halogenated compounds, namely, trans-3-[4-(4-fluorobenzoyl) piperidinyl]-2-hydroxy-1,2,3,4-tetrahydronaphthalene (28b) (Ki = 2.7 nM, VAChT/sigma selectivity index = 70), trans-3-[4-(5-iodothienylcarbonyl) piperidinyl]-2-hydroxy-1,2,3,4-tetrahydronaphthalene (28h) (Ki = 0.66 nM, VAChT/sigma selectivity index = 294), and 5-amino-3-[4-(p-fluorobenzoyl) piperidinyl]-2-hydroxy-1,2,3,4,-tetrahydronaphthalene (30b) (Ki = 2.40 nM, VAChT/sigma selectivity index = 410) display moderate to high selectivity for VAChT. These three compounds can be synthesized with the corresponding radioisotopes so as to serve as PET/SPECT probes for imaging the VAChT in vivo.
