1220294-96-1

Basic information

• Product Name: 2,4-di-p-tolyl-2,3,3a,4,9,9a-hexahydrobenzo[f]isoindol-1-one
• CAS NO: 1220294-96-1
• Molecular Weight: 367.491
• Mol File: 1220294-96-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,4-di-p-tolyl-2,3,3a,4,9,9a-hexahydrobenzo[f]isoindol-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-di-p-tolyl-2,3,3a,4,9,9a-hexahydrobenzo[f]isoindol-1-one(1220294-96-1)
• EPA Substance Registry System: 2,4-di-p-tolyl-2,3,3a,4,9,9a-hexahydrobenzo[f]isoindol-1-one(1220294-96-1)

Safety Data

• Hazardous Substances Data: 1220294-96-1(Hazardous Substances Data)

Upstream product

• 106-38-7 para-bromotoluene 
• 1451066-20-8 N-allyl-N-p-tolylcinnamamide 

Relevant articles and documents

Tuned C-H functionalization to construct aza-podophyllotoxin/aza- conidendrin derivatives by means of domino cyclization

An efficient domino cyclization method for the construction of aza-podophyllotoxin/aza-conidendrin derivatives has been established. Reactions of different dienes with aryl halides in the presence of a palladium catalytic system produced different kinds of podophyllotoxin derivatives through a highly regioselective C-H functionalization. Treatment of dienes with aryl halides that have electron-withdrawing substituents on the phenyl ring created aza-podophyllotoxin derivatives by means of the functionalization of the C-H bonds ortho to the C-Halide bonds of the incoming aryl halides. The reaction of dienes with 1-iodobenzene or aryl halides that incorporate electron-donating groups produced azaconidendrin derivatives by means of the functionalization of both sp3 C-H and sp2 C-H bonds. The regioselective C-H functionalization for the formation of different pseudo-podophyllotoxin/- conidendrin derivatives is proven by analyses of the 1H NMR spectra of the products and selective X-ray analyses of the structures of the products. Thus the palladium-catalyzed domino cyclization of 1,6-dienes for the preparation of aza-podophyllotoxin/aza-conidendrin derivatives can be controlled by selectively controlling the C-H functionalization.