1220915-50-3Relevant articles and documents
Parallel synthesis of novel 3-substituted 1-ethyl-6-methylpyrimido[4,5-c] pyridazine-5,7(1H,6H)-dione Analogs
Chen, Yongsheng,Barber, Jack R.,Ng, Shi Chung,Zhou, Yuefen
experimental part, p. 821 - 832 (2010/05/18)
A library of novel 1H-pyrimido[4,5-c]pyridazine-5,7-dione analogs was prepared in a parallel fashion via the cyclization of 6-(1-ethylhydrazinyl)-3- methylpyrimidine-2,4(1H,3H)-dione (4) with-bromoketones and was then isolated by a two-step purification method with 90% purity. Both the library synthesis and purification method proved suitable for analogs with a high diversity of substitution at the 3-position including various alkyl, aryl, and heteroaryl groups.