1221-70-1

Basic information

• Product Name: DesMethyl DoxylaMine
• Synonyms: DesMethyl DoxylaMine;DesMethyl DoxylaMine Succinate
• CAS NO: 1221-70-1
• Molecular Formula: C₁₆H₂₀N₂O
• Molecular Weight: 256.3428
• Product Categories: Amines, Aromatics, Heterocycles, Impurities, Neurochemicals, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1221-70-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: DesMethyl DoxylaMine(CAS DataBase Reference)
• NIST Chemistry Reference: DesMethyl DoxylaMine(1221-70-1)
• EPA Substance Registry System: DesMethyl DoxylaMine(1221-70-1)

Safety Data

• Hazardous Substances Data: 1221-70-1(Hazardous Substances Data)

Usage

Uses

Desmethyl Doxylamine is an impurity of Doxylamine (D562000), an H1 Histamine receptor antagonist used as a antihistaminic and sedative agent.

Upstream product

• 107-99-3 2-(dimethylamino)ethyl chloride 
• 31796-72-2 phenyl(2-pyridinyl)methanol 

Relevant articles and documents

Preparation method of doxylamine succinate impurity C

The invention discloses a preparation method of a doxylamine succinate impurity C. The preparation method comprises steps as follows: alpha-phenyl-2-pyridinemethanol and an organic solvent are added to a reactor, stirred and dissolved, after air in the reactor is subjected to N2 replacement, alkali liquor is added, a 2-dimethylaminoethyl chloride solution is dropwise added during stirring, a mixed solution is heated to produce backflow and is cooled after the reaction, water is added to a reaction product, a mixture is layered and purified, and a target product is obtained. According to the preparation method, alpha-phenyl-2-pyridinemethanol is taken as a raw material and subjected to an elimination reaction with 2-dimethylaminoethyl chloride under the alkaline condition, and the target product is obtained; the method has the advantages of adopting mild reaction conditions and short synthesis route and being simple and convenient to operate and can be applied to qualitative and quantitative analysis of impurities in doxylamine succinate production, and therefore, quality standard of doxylamine succinate can be improved; the product is high in yield and purity.