1221447-46-6Relevant articles and documents
Design, synthesis, evaluation and QSAR analysis of N1-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors
Takahashi, Jun,Hijikuro, Ichiro,Kihara, Takeshi,Murugesh, Modachur G.,Fuse, Shinichiro,Kunimoto, Ryo,Tsumura, Yoshinori,Akaike, Akinori,Niidome, Tetsuhiro,Okuno, Yasushi,Takahashi, Takashi,Sugimoto, Hachiro
scheme or table, p. 1718 - 1720 (2010/06/19)
We synthesized a series of N1-substituted norcymserine derivatives 7a-p and evaluated their anti-cholinesterase activities. In vitro evaluation showed that the pyridinylethyl derivatives 7m-o and the piperidinylethyl derivative 7p improved the anti-butyrylcholinesterase activity by approximately threefold compared to N1-phenethylnorcymserine (PEC, 2). A quantitative structure-activity relationship (QSAR) study indicated that logS might be a key feature of the improved compounds.
