1221499-55-3

Basic information

• Product Name: C₁₈H₁₆N₄O₃
• CAS NO: 1221499-55-3
• Molecular Weight: 336.35
• Mol File: 1221499-55-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₆N₄O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₆N₄O₃(1221499-55-3)
• EPA Substance Registry System: C₁₈H₁₆N₄O₃(1221499-55-3)

Safety Data

• Hazardous Substances Data: 1221499-55-3(Hazardous Substances Data)

Upstream product

• 36725-28-7 6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone 
• 103-84-4 Acetanilid 
• 81937-39-5 2-ethoxycarbonyl-3-(4-acetamidobenzoyl)butyric acid ethyl ester 
• 555-16-8 4-nitrobenzaldehdye 
• 36725-28-7 OR-1855 
• 63514-63-6 N-(4-(2-bromopropionyl)phenyl)acetamide 
• 16960-49-9 N-(4-propionylphenyl)acetamide 

Relevant articles and documents

Synthesis and anti-congestive heart failure activity of novel levosimendan analogues

A series of levosimendan analogues were designed and synthesized, employing the Friedel-Crafts reaction, hydrolysis, and cyclization from the key intermediate compound R(-)-6-(4-aminophenyl)-5-methyl-4, 5-dihydro-3(2H)- pyridazinone, which was obtained from the starting material, acetanilide. These compounds, except 1b, exhibited potent anti-congestive heart failure activities, especially the compounds 1e and 1k, which showed more effective action than levosimendan. Springer Science+Business Media, LLC 2010.