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1222368-75-3

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1222368-75-3 Usage

Description

4-Bromo-2-(cyclopropylcarbonyl)-1-fluorobenzene is a halogenated aromatic chemical compound with the molecular formula C11H8BrFO. It features a cyclopropylcarbonyl group attached to a benzene ring, which is substituted with a bromine atom at the 4-position and a fluorine atom at the 1-position. 4-Bromo-2-(cyclopropylcarbonyl)-1-fluorobenzene is known for its unique reactivity and steric properties due to the presence of the cyclopropylcarbonyl group, as well as its versatility in chemical modifications and functional group transformations, thanks to the bromo and fluoro substituents.

Uses

Used in Pharmaceutical Synthesis:
4-Bromo-2-(cyclopropylcarbonyl)-1-fluorobenzene is used as a building block in the synthesis of pharmaceuticals. Its unique reactivity and steric properties, along with the versatility of the bromo and fluoro substituents, make it a valuable intermediate for the development of new drugs.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-Bromo-2-(cyclopropylcarbonyl)-1-fluorobenzene serves as a key intermediate for the creation of novel compounds with potential therapeutic applications. Its structural features allow for the design of molecules with specific biological activities and improved pharmacokinetic properties.
Used in Agrochemicals:
4-Bromo-2-(cyclopropylcarbonyl)-1-fluorobenzene also has potential applications in agrochemicals, where it can be utilized as a starting material for the synthesis of new pesticides or other agrochemical products. Its unique structural features can contribute to the development of more effective and environmentally friendly agrochemicals.
Used in Materials Science:
In materials science, 4-Bromo-2-(cyclopropylcarbonyl)-1-fluorobenzene can be employed in the development of new materials with specific properties. Its reactivity and structural features make it a promising candidate for the synthesis of advanced materials with applications in various industries.
Overall, 4-Bromo-2-(cyclopropylcarbonyl)-1-fluorobenzene is a valuable synthetic building block with diverse applications in organic and medicinal chemistry, as well as in agrochemicals and materials science. Its unique properties and versatility in chemical modifications make it an important compound for the development of new drugs, materials, and other products.

Check Digit Verification of cas no

The CAS Registry Mumber 1222368-75-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,2,3,6 and 8 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1222368-75:
(9*1)+(8*2)+(7*2)+(6*2)+(5*3)+(4*6)+(3*8)+(2*7)+(1*5)=133
133 % 10 = 3
So 1222368-75-3 is a valid CAS Registry Number.

1222368-75-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (5-Bromo-2-fluorophenyl)(cyclopropyl)methanone

1.2 Other means of identification

Product number -
Other names (5-bromo-2-fluorophenyl)-cyclopropylmethanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1222368-75-3 SDS

1222368-75-3Relevant articles and documents

INHIBITORS OF ENL/AF9 YEATS

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Paragraph 00172-00173, (2021/06/26)

Methods and compositions for treating leukemia are disclosed. Acylated 6-aminoindoles, acylated 6-aminopyrrolopyridines and acylated 3-aminopyrrolo[3,2-c]pyridazines of the following formula inhibit ENL/AF9 YEATS and are therefore useful for treating leukemia.

3-AMINO-5-PHENYL-5,6-DIHYDRO-2H-[1,4]OXAZINES

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Page/Page column 33-34, (2011/04/14)

The present invention relates to 3-Amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. T

2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics

Zeng, Qingping,Bourbeau, Matthew P.,Wohlhieter, G. Erich,Yao, Guomin,Monenschein, Holger,Rider, James T.,Lee, Matthew R.,Zhang, Shiwen,Lofgren, Julie,Freeman, Daniel,Li, Chun,Tominey, Elizabeth,Huang, Xin,Hoffman, Douglas,Yamane, Harvey,Tasker, Andrew S.,Dominguez, Celia,Viswanadhan, Vellarkad N.,Hungate, Randall,Zhang, Xiaoling

scheme or table, p. 1652 - 1656 (2010/07/15)

A series of 2-aminothiadiazole of inhibitors of AKT1 is described. SAR relationships are discussed, along with selectivity for protein kinase A (PKA) and cyclin-dependent kinase 2 (CDK2). Moderate selectivity observed in several compounds for AKT1 versus PKA is rationalized by X-ray crystallographic analysis. Key compounds showed activity in cellular assays measuring phosphorylation of two AKT substrates, PRAS40 and FKHRL1. Compound 30 was advanced to a mouse liver PD assay, where it showed dose-dependent inhibition of AKT activity, as measured by the inhibition of phospho-PRAS40.

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