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122299-11-0

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122299-11-0 Usage

General Description

EGLIN C (41-49) is a peptide chemical compound that is a potent and specific inhibitor of human neutrophil elastase (HNE), an enzyme involved in inflammatory processes and tissue damage. This peptide is a synthetic analog of the natural elastase inhibitor elafin, with a modified cysteine residue that enhances its stability and efficacy. EGLIN C (41-49) has been shown to effectively inhibit HNE activity in vitro and in vivo, making it a potential candidate for the development of anti-inflammatory drugs and treatments for conditions such as chronic obstructive pulmonary disease (COPD), cystic fibrosis, and other inflammatory disorders. Its ability to specifically target and inhibit HNE without affecting other related enzymes makes it a promising compound for further research and development in the field of anti-inflammatory therapeutics.

Check Digit Verification of cas no

The CAS Registry Mumber 122299-11-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,2,9 and 9 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 122299-11:
(8*1)+(7*2)+(6*2)+(5*2)+(4*9)+(3*9)+(2*1)+(1*1)=110
110 % 10 = 0
So 122299-11-0 is a valid CAS Registry Number.
InChI:InChI=1/C48H78N12O15/c1-23(2)18-31(41(68)53-30(11-9-17-52-48(49)50)40(67)55-33(20-27-12-14-28(63)15-13-27)43(70)58-35(22-61)47(74)75)54-44(71)34(21-36(64)65)56-42(69)32(19-24(3)4)57-46(73)38(26(7)62)60-45(72)37(25(5)6)59-39(66)29-10-8-16-51-29/h12-15,23-26,29-35,37-38,51,61-63H,8-11,16-22H2,1-7H3,(H,53,68)(H,54,71)(H,55,67)(H,56,69)(H,57,73)(H,58,70)(H,59,66)(H,60,72)(H,64,65)(H,74,75)(H4,49,50,52)/t26-,29+,30+,31+,32+,33+,34+,35+,37+,38+/m1/s1

122299-11-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name (3S)-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[[(2S)-2-[[(2S,3R)-3-hydroxy-2-[[(2S)-3-methyl-2-[[

1.2 Other means of identification

Product number -
Other names (3S)-4-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1-[[(2S)-1,3-dihydroxy-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[[(2S)-2-[[(2S,3R)-3-hydroxy-2-[[(2S)-3-methyl-2-[[(2S)-pyrrolidine-2-carbonyl]amino]butanoyl]amino]butanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:122299-11-0 SDS

122299-11-0Downstream Products

122299-11-0Relevant articles and documents

Amino acids and peptides. XXXVII. Synthesis of stereoisomeric nonapeptides corresponding to sequence 41-49 of eglin c and examination of their inhibitory activity against human leukocyte cathepsin G and α-chymotrypsin

Fujii,Tsuboi,Asada,Nagamatsu,Yamamoto,Okada

, p. 1518 - 1521 (2007/10/02)

A nonapeptide, H-Ser-Pro-Val-Thr-Leu-Asp-Leu-Arg-Tyr-OH, corresponding to sequence 41-49 of eglin c inhibited leukocyte cathepsin G and α-chymotrypsin with K(i) values of 2.2 x 10-5 and 7.2 x 10-6 M, respectively, although eglin c it

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