122455-36-1

Basic information

• Product Name: 2-IODO-3-FLUORONITROBENZENE
• Synonyms: 1-fluoro-2-iodo-3-nitrobenzene;Benzene, 1-fluoro-2-iodo-3-nitro-
• CAS NO: 122455-36-1
• Molecular Formula: C₆H₃FINO₂
• Molecular Weight: 266.92
• Mol File: 122455-36-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 283.136 °C at 760 mmHg
• Flash Point: 125.036 °C
• Appearance: /
• Density: 2.093 g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.635
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-IODO-3-FLUORONITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-IODO-3-FLUORONITROBENZENE(122455-36-1)
• EPA Substance Registry System: 2-IODO-3-FLUORONITROBENZENE(122455-36-1)

Safety Data

• Hazardous Substances Data: 122455-36-1(Hazardous Substances Data)

Usage

General Description

2-IODO-3-FLUORONITROBENZENE is a chemical compound with the molecular formula C6H4FNO2I. It is a pale yellow crystalline solid that is used in organic synthesis to introduce both iodine and fluorine atoms into aromatic compounds. It is commonly used as an intermediate in the production of pharmaceuticals and agrochemicals. 2-IODO-3-FLUORONITROBENZENE is also used in the manufacturing of dyes, pigments, and other specialty chemicals. 2-IODO-3-FLUORONITROBENZENE is considered to be hazardous due to its potential for causing skin and eye irritation, as well as being harmful if inhaled or ingested. Therefore, it requires careful handling and storage to prevent accidents and exposure.

InChI:InChI=1/C6H3FINO2/c7-4-2-1-3-5(6(4)8)9(10)11/h1-3H

Upstream product

• 402-67-5 3-fluoro-1-nitrobenzene 
• 122455-35-0 2-fluoro-6-nitrophenyl trifluoromethanesulfonate 
• 872-50-4 1-methyl-pyrrolidin-2-one 
• 10394-64-6 3-nitro-5-iodoaniline 

Downstream Products

• 122455-37-2 2-Iodo-3-fluoroaniline hydrochloride 
• 706752-99-0 3-fluoro-2-iodoaniline 

Relevant articles and documents

Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles

2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.

STEROID RECEPTOR MODULATOR COMPOUNDS AND METHODS

Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.

Steroid receptor modulator compounds and methods

Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.