1225335-95-4

Basic information

• Product Name: 2-((4-methoxyphenyl)ethynyl)phenyl acetate
• Synonyms: 2-((4-methoxyphenyl)ethynyl)phenyl acetate
• CAS NO: 1225335-95-4
• Molecular Weight: 266.296
• Mol File: 1225335-95-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-((4-methoxyphenyl)ethynyl)phenyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((4-methoxyphenyl)ethynyl)phenyl acetate(1225335-95-4)
• EPA Substance Registry System: 2-((4-methoxyphenyl)ethynyl)phenyl acetate(1225335-95-4)

Safety Data

• Hazardous Substances Data: 1225335-95-4(Hazardous Substances Data)

Upstream product

• 32865-61-5 2-iodophenyl acetate 
• 768-60-5 4-methoxyphenylacetylen 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 19234-04-9 2-(p-methoxyphenyl)-benzo[b]furan 
• 1225336-00-4 2-(4-methoxyphenyl)benzofuran-3-carbonitrile 
• 3923-14-6 methyl 2-(4-methoxyphenyl)benzo[b]furan-3-carboxylate 
• 202914-74-7 2-[(4-methoxyphenyl)ethynyl]phenol 

Relevant articles and documents

A concise route to dihydrobenzo[b]furans: Formal total synthesis of (+)-lithospermic acid

A sequence of Sonogashira coupling, Pd(II)-catalyzed carbonylative annulation, and benzofuran reduction (Mg, MeOH, NH4Cl) provides a convergent and modular synthetic route to trans-2-aryl-2,3-dihydrobenzo[b]furan- 3-carboxylates, which are a structural feature of numerous biologically active natural products. This versatile strategy was applied to the formal total synthesis of the anti-HIV natural product (+)-lithospermic acid.