1226781-82-3

Basic information

• Product Name: tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate
• Synonyms: tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate;2-(Methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylic acid tert-butyl ester;tert-butyl 2-methanesulfonyl-2H,4H,5H,6H-pyrrolo[3,4-c]pyrazole-5-carboxylate;MK-3103 Intermediate IV;tert-butyl 2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylate;Pyrrolo[3,4-c]pyrazole, 2,4,5,6-tetrahydro-2-(methylsulfonyl)-, benzenesulfonate;Omarigliptin Impurity 10;Omarigliptin Intermediate 3
• CAS NO: 1226781-82-3
• Molecular Formula: C₁₁H₁₇N₃O₄S
• Molecular Weight: 287.33538
• EINECS: -0
• Product Categories: Omarigliptin intermediate
• Mol File: 1226781-82-3.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 441.1±55.0 °C(Predicted)
• Appearance: /
• Density: 1.40±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -1.95±0.20(Predicted)
• CAS DataBase Reference: tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate(1226781-82-3)
• EPA Substance Registry System: tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate(1226781-82-3)

Safety Data

• Hazardous Substances Data: 1226781-82-3(Hazardous Substances Data)

Usage

General Description

Tert-butyl 2-(methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate is a chemical compound with potential pharmaceutical applications. It is a carboxylate ester that contains a sulfur atom and a pyrazole ring. The tert-butyl group and the methylsulfonyl group contribute to the compound's stability and lipophilicity, potentially making it suitable for formulations in drug delivery systems. The pyrrolopyrazole structure suggests potential biological activity, particularly in the modulation of protein kinases and as anti-inflammatory agents. Further research and development may reveal its potential as a drug candidate for various medical conditions.

Upstream product

• 101385-93-7 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1280210-79-8 2,6-dihydropyrrole [3,4-c]pyrazole-5(4H)-carboxylic acid tert-butyl ester 
• 124-63-0 methanesulfonyl chloride 
• 905274-02-4 tert-butyl (3Z)-3-[(dimethylamino)methylene]-4-oxopyrrolidine-1-carboxylate 
• 6573-19-9 1,4,5,6-tetrahydropyrrolo[3, 4-c]pyrazole 
• 157327-42-9 3-(dimethylaminomethylene)-4-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 62773-95-9 N-(2,2-dimethoxyethyl)prop-2-yn 1-amine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 657428-42-7 4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester 

Downstream Products

• 1280210-80-1 2-(methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-5-ium benzenesulfonate 
• 1226781-44-7 Omarigliptin 
• 1226781-87-8 tert-butyl {(2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-yl}carbamate 
• 1226781-80-1 2-methylsulfonic acid-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole 
• 1280210-98-1 tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-{2-[1-(methylsulfonyl)-1H-pyrazol-4-yl]ethyl}piperidin-3-yl]carbamate 
• 1280210-97-0 tert-butyl {(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(pyridin-2-ylmethyl)piperidin-3-yl}carbamate 
• 1280210-96-9 tert-butyl {(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(pyrazin-2-ylacetyl)piperidin-3-yl}carbamate 
• 1280210-95-8 tert-butyl {(2R,3S,5R)-1-acetyl-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-3-yl}carbamate 

Relevant articles and documents

Tetrahydropyranyl amine derivatives used as DPP-IV inhibitors, and a pharmaceutical composition, a preparation and uses of the derivatives

The invention provides tetrahydropyranyl amine derivatives used as DPP-IV inhibitors and having structures shown as a formula I, and a pharmaceutical composition, a preparation and uses of the derivatives. The derivatives have good DPP-IV inhibiting activity, excellent pharmacodynamic performance and lower toxicity. R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are hydrogen or deuterium independently and at least comprise a deuterium.

Aminopyran ring derivative and its composition and application wherein the dipeptidyl peptidase IV (DPP-IV) inhibitor is used for preparing the drugs for treating metabolic diseases

The present invention relates to an aminopyran ring derivative and its composition and application, specifically speaking, relating to the aminopyran ring derivative represented by the general formula (I) or its stereoisomer, pharmaceutically acceptable salt, prodrug, pharmaceutical composition containing the derivative and the preparation of dipeptidyl peptidase IV (DPP-IV) inhibitor for medical use, wherein the definitions of the substituents in the general formula (I) are the same as those defined in the patent specification.

AMINO PYRANOID RING DERIVATIVE AND COMPOSITION AND USE THEREOF

The present invention relates to an amino pyran ring derivative and a composition and use thereof, and in particular, to an amino pyran ring derivative represented by general formula (I) or a stereoisomer, a pharmaceutically acceptable salt or a prodrug thereof, a pharmaceutical composition comprising the derivative, and their medical use in the manufacture of a di-peptidyl peptidase IV (DPP-IV) inhibitor, in formula (I) the substituents are defined the same as those in the specification.