1227-45-8

Basic information

• Product Name: 1,3-bis(4-methoxyphenyl)thiourea
• Synonyms: 1,3-bis(4-methoxyphenyl)thiourea;1,3-Bis(p-methoxyphenyl)thiourea;4,4'-DIMETHOXYTHIOCARBANILIDE
• CAS NO: 1227-45-8
• Molecular Formula: C₁₅H₁₆N₂O₂S
• Molecular Weight: 288.3647
• Mol File: 1227-45-8.mol
• Article Data: 40

Chemical Properties

• Melting Point: 185.0 to 189.0 °C
• Boiling Point: 421.9°Cat760mmHg
• Flash Point: 209°C
• Appearance: /
• Density: 1.277g/cm³
• Vapor Pressure: 2.51E-07mmHg at 25°C
• Refractive Index: 1.683
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.10±0.70(Predicted)
• CAS DataBase Reference: 1,3-bis(4-methoxyphenyl)thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis(4-methoxyphenyl)thiourea(1227-45-8)
• EPA Substance Registry System: 1,3-bis(4-methoxyphenyl)thiourea(1227-45-8)

Safety Data

• RTECS: YS2750000
• Hazardous Substances Data: 1227-45-8(Hazardous Substances Data)

Usage

General Description

1,3-bis(4-methoxyphenyl)thiourea is a chemical compound that features a thiourea core, which is a type of organic compound featuring two amine functional groups (-NH2) flanked by a carbonyl group (C=O). The amine groups are further functionalized with methoxyphenyl groups, which contain a phenyl ring (essentially a benzene ring) that is further modified by a methoxy group (-OCH3). This type of structure could make the compound a potential ligand for various metal ions, and the compound may exhibit useful properties including antimicrobial activities or unique optical properties. Its potential uses, however, largely depend on how the compound interacts with other molecules and its surrounding environment. Having said this, concrete information on its specific uses and properties is limited, suggesting that this compound may not be widely utilized or studied.

InChI:InChI=1/C15H16N2O2S/c1-18-13-7-3-11(4-8-13)16-15(20)17-12-5-9-14(19-2)10-6-12/h3-10H,1-2H3,(H2,16,17,20)

Upstream product

• 75-15-0 carbon disulfide 
• 104-94-9 4-methoxy-aniline 
• 463-71-8 thiophosgene 
• 2284-20-0 4-Methoxyphenyl isothiocyanate 
• 64-17-5 ethanol 
• 29336-07-0 N-(4-methoxyphenyl)-N’-(4-nitrophenyl)thiourea 
• 17356-08-0 thiourea 
• 624-84-0 formic acid hydrazide 
• 103-72-0 phenyl isothiocyanate 
• 102-08-9 N,N-diphenylthiourea 
• 1219-96-1 N-(p-methoxyphenyl)-N'-phenylthiourea 
• 1439-36-7 1-triphenylphosphoranylidene-2-propanone 
• 534-18-9 sodium trithiocarbonate 
• 56-23-5 tetrachloromethane 

Downstream Products

• 32826-88-3 3-(4-methoxyphenyl)-1,3-thiazolidine-2,4-dione 
• 39139-62-3 3-(4-methoxyphenyl)-2-(4-methoxyphenylimino)-1,3-thiazolidine-4-one 
• 855760-40-6 (4-methoxy-phenyl)-(6-methoxy-2-phenyl-[4]quinolyl)-amine 
• 73318-39-5 N,N'-bis-(4-methoxy-phenyl)-S-methyl-isothiourea 
• 7669-39-8 [3-(4-methoxy-phenyl)-2-(4-methoxy-phenylimino)-4-oxo-thiazolidin-5-yl]-acetic acid 
• 68339-75-3 1,3-bis-(4-methoxyphenyl)guanidine 
• 874-90-8 4-methoxybenzonitrile 
• 104-94-9 4-methoxy-aniline 
• 5961-59-1 N-methyl-N-(4-methoxyphenyl)amine 
• 878533-46-1 1,3-bis-(4-methoxy-phenyl)-5-phenyl-2-thioxo-imidazolidin-4-one 
• 81108-66-9 1,3-di-(4-methoxyphenyl)-2-thiobarbituric acid 
• 22007-38-1 O-ethyl N-(4-methoxyphenyl)thiocarbamate 
• 1227-44-7 N,N'-bis(4-methoxyphenyl)urea 
• 64830-89-3 S-methyl-N,N′-bis(4-methoxyphenyl)isothiourea hydroiodide 

Relevant articles and documents

Chemistry of phosphorus ylides: Part 45 synthesis of phosphoranylidene, thietane, azetidine and thiazinane derivatives as potent chemo preventative agents

Reactions of nucleophilic active phosphacumulenes with iso(thio)cyanate compounds were performed. The reaction products depend on the nature of the reagent, substrate and the condition of the reaction used. New heterocyclic 4-membered or 6-membered sulfur

Di-tert-butyl peroxide (DTBP)-mediated synthesis of symmetrical N,N′-disubstituted urea/thiourea motifs from isothiocyanates in water

ABATRACT: A direct approach to N,N′-disubstituted urea/thiourea from the self-condensation reactions of isothiocyanates in water has been developed. This access tolerated a wide range of functional groups on the aromatic ring, providing a practical and environment-friendly process to N,N′-disubstituted urea/thiourea in moderate to excellent yields from safe and easily available starting materials. A plausible mechanism of the desulfurization self-condensation reaction for urea was also proposed and the role of di-tert-butyl peroxide (DTBP) and copper catalyst in the present strategy was demonstrated with the help of ESI mass spectrometry of intermediate studies.

Novel non-peptidic small molecule inhibitors of secreted aspartic protease 2 (SAP2) for the treatment of resistant fungal infections

Targeting secreted aspartic protease 2 (SAP2), a kind of virulence factor, represents a new strategy for antifungal drug discovery. In this report, the first-generation of small molecule SAP2 inhibitors was rationally designed and optimized using a structure-based approach. In particular, inhibitor 23h was highly potent and selective and showed good antifungal potency for the treatment of resistant Candida albicans infections.