1227182-14-0

Basic information

• Product Name: (1R,3aS,4R,5S,9bR)-ethyl 3-(4-bromophenyl)-5-(nitromethyl)-4-propyl-1,3,3a,4,5,9b-hexahydronaphtho[2,1-c]isoxazole-1-carboxylate
• CAS NO: 1227182-14-0
• Molecular Weight: 503.393
• Mol File: 1227182-14-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,3aS,4R,5S,9bR)-ethyl 3-(4-bromophenyl)-5-(nitromethyl)-4-propyl-1,3,3a,4,5,9b-hexahydronaphtho[2,1-c]isoxazole-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,3aS,4R,5S,9bR)-ethyl 3-(4-bromophenyl)-5-(nitromethyl)-4-propyl-1,3,3a,4,5,9b-hexahydronaphtho[2,1-c]isoxazole-1-carboxylate(1227182-14-0)
• EPA Substance Registry System: (1R,3aS,4R,5S,9bR)-ethyl 3-(4-bromophenyl)-5-(nitromethyl)-4-propyl-1,3,3a,4,5,9b-hexahydronaphtho[2,1-c]isoxazole-1-carboxylate(1227182-14-0)

Safety Data

• Hazardous Substances Data: 1227182-14-0(Hazardous Substances Data)

Upstream product

• 10468-46-9 N-(4-bromophenyl)hydroxylamine 

Relevant articles and documents

Water-more than just a green solvent: a stereoselective one-pot access to all-chiral tetrahydronaphthalenes in aqueous media

A facile and highly stereose-lective construction of heavily function-alized chiral tetrahydronaphthalene skeletons fused with an oxazolidine moiety has been developed. The pro-cess involves an organocatalytic tandem Michael/nitrone formation/in-tramolecular [3+2] nitrone-olefin cy-cloaddition in aqueous media. Using rationally designed substrates, the reaction conditions have been optimized and the one-pot process has been ap-plied to a series of nitroolefin acrylates and aldehydes. The N-hydroxyphenyla-mine component used in the second step has also been varied. The stereo-chemistry of one product has been verified by an X-ray crystal structure determination. The water used in the strategy not only constitutes an envi-ronmentally benign solvent, but also helps to improve the reactivity and ste-reoselectivity.