1227210-37-8 Usage
Description
5-Fluoro-2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is a chemical compound characterized by a fluoro-substituted aniline with a boronic ester functionality. It is defined by its molecular formula C14H20BFNO2 and a molecular weight of 265.12 g/mol. 5-Fluoro-2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is recognized for its role as a building block in organic synthesis, especially in the creation of pharmaceuticals and agrochemicals.
Uses
Used in Pharmaceutical Industry:
5-Fluoro-2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is utilized as a key intermediate in the synthesis of pharmaceuticals due to its ability to impart specific biological properties to target molecules. Its incorporation can enhance the efficacy and selectivity of drug candidates.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Fluoro-2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline serves as a crucial component in the development of new agrochemicals, potentially improving the performance and selectivity of pesticides and other agricultural chemicals.
Used in Organic Synthesis:
5-Fluoro-2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is employed as a reagent in Suzuki-Miyaura coupling reactions, a cross-coupling method pivotal for constructing complex organic molecules. Its boronic ester group is particularly valuable in facilitating these reactions, enabling the formation of new carbon-carbon bonds.
Used in Drug Discovery and Development:
5-Fluoro-2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is leveraged in drug discovery and development processes, where its fluoro-substituted aniline moiety can confer unique physicochemical properties to molecules under investigation, potentially leading to the creation of novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 1227210-37-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,7,2,1 and 0 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1227210-37:
(9*1)+(8*2)+(7*2)+(6*7)+(5*2)+(4*1)+(3*0)+(2*3)+(1*7)=108
108 % 10 = 8
So 1227210-37-8 is a valid CAS Registry Number.
1227210-37-8Relevant articles and documents
Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability
Young, Wendy B.,Barbosa, James,Blomgren, Peter,Bremer, Meire C.,Crawford, James J.,Dambach, Donna,Eigenbrot, Charles,Gallion, Steve,Johnson, Adam R.,Kropf, Jeffrey E.,Lee, Seung H.,Liu, Lichuan,Lubach, Joseph W.,MacAluso, Jen,MacIejewski, Pat,Mitchell, Scott A.,Ortwine, Daniel F.,Di Paolo, Julie,Reif, Karin,Scheerens, Heleen,Schmitt, Aaron,Wang, Xiaojing,Wong, Harvey,Xiong, Jin-Ming,Xu, Jianjun,Yu, Christine,Zhao, Zhongdong,Currie, Kevin S.
, p. 575 - 579 (2016/01/09)
BTK inhibitor GDC-0834 (1) was found to be rapidly metabolized in human studies, resulting in a suspension of clinical trials. The primary route of metabolism was through cleavage of the acyclic amide bond connecting the terminal tetrahydrobenzothiophene
PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS
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Page/Page column 103-104, (2010/06/15)
Compounds of Formula (I) that inhibit Btk are described herein. Pharmaceutical compositions comprising at least one compound of Formula (I), together with at least one pharmaceutically acceptable vehicle chosen from carriers, adjuvants, and excipients, ar
