1227700-88-0

Basic information

• Product Name: 2-hydroxy-5-(2-methylquinolin-7-yl)benzonitrile
• Synonyms: 2-hydroxy-5-(2-methylquinolin-7-yl)benzonitrile
• CAS NO: 1227700-88-0
• Molecular Weight: 260.295
• Mol File: 1227700-88-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-5-(2-methylquinolin-7-yl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-5-(2-methylquinolin-7-yl)benzonitrile(1227700-88-0)
• EPA Substance Registry System: 2-hydroxy-5-(2-methylquinolin-7-yl)benzonitrile(1227700-88-0)

Safety Data

• Hazardous Substances Data: 1227700-88-0(Hazardous Substances Data)

Upstream product

• 1227700-94-8 2-benzoxy-5-(2-methylquinolin-7-yl)benzonitrile 
• 1227700-93-7 2-methoxymethoxy-5-(2-methylquinolin-7-yl)benzonitrile 
• 939052-79-6 2-methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline 
• 40530-18-5 5-bromo-2-hydroxybenzonitrile 

Downstream Products

• 1227700-90-4 2-cyano-4-(2-methylquinolin-7-yl)phenyl triflate 

Relevant articles and documents

Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5

The metabotropic glutamate receptor subtype 5 (mGluR5) has been implicated in numerous neuropsychiatric disorders including addiction. We have discovered that the rigid diaryl alkyne template, derived from the potent and selective noncompetitive mGluR5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP), can serve to guide the design of novel quinoline analogues and pharmacophore optimization has resulted in potent mGluR5 noncompetitive antagonists (EC50 range 60-100 nM) in the quinoline series.