1228178-53-7Relevant articles and documents
An efficient concomitant synthesis of O-succinimidyl-(9H-fluoren-9-yl methoxy arbonylamino)peptidyl carbamates and their application in the synthesis of oligo-α-peptidyl ureas
Sureshbabu, Vommina V.,Chennakrishnareddy, Gundala,Naik, Shankar A.,Kantharaju
experimental part, p. 69 - 76 (2010/05/02)
An efficient method for the synthesis of O-succinimidyl (9H-fluorene-9-yl methoxycarbonylamine) peptidyl carbamates from the corresponding N α-Fmoc peptidyl isocyanates through the concomitant Curtius rearrangement of NαFmoc peptidyl acid azide and coupling with N-hydroxysuccinimide is described. The introduction of urea moiety at various positions in peptidyl backbone of VALVAL hexapeptide sequence has been carried out by the fragment coupling using peptidyl carbamates. All the oligo-a-peptidyl ureas are isolated as crystalline solids in 80-85% yield and have been fully characterized by 1H and 13C NMR and mass spectrometry.