1228182-47-5 Usage
Description
Fenbendazole-d3 is a deuterated analog of the benzimidazole anthelmintic fenbendazole, designed for use as an internal standard in the quantification of fenbendazole by gas chromatography (GC) or liquid chromatography-mass spectrometry (LC-MS). It exhibits anthelmintic properties and is active against Giardia in vitro, with an IC50 value of 0.3 μM. Fenbendazole-d3 also demonstrates neuroprotective effects, as it prevents infiltration of parasites into the brain in a rabbit model of E. cuniculi infection and activates HIF-1α, thereby preventing oxidative stress-induced death in primary neurons in vitro.
Uses
Used in Pharmaceutical Industry:
Fenbendazole-d3 is used as an internal standard for the quantification of fenbendazole by GCor LC-MS, ensuring accurate and reliable measurements in pharmaceutical research and development.
Used in Veterinary Medicine:
Fenbendazole-d3 is used as an anthelmintic agent for the treatment of nematode infections in animals, providing effective control and prevention of parasitic diseases.
Used in Research and Development:
Fenbendazole-d3 is used in research studies to investigate the anthelmintic properties of fenbendazole, its activity against Giardia, and its neuroprotective effects in various models of infection and oxidative stress. This helps in understanding the mechanism of action and potential applications of fenbendazole in treating parasitic infections and neurodegenerative diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 1228182-47-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,8,1,8 and 2 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1228182-47:
(9*1)+(8*2)+(7*2)+(6*8)+(5*1)+(4*8)+(3*2)+(2*4)+(1*7)=145
145 % 10 = 5
So 1228182-47-5 is a valid CAS Registry Number.
