1228547-99-6 Usage
Description
(S)-2-O-TOLYLPIPERIDINE is a chiral piperidine derivative that features a piperidine ring with a tolyl group attached to the second carbon atom. (S)-2-O-TOLYLPIPERIDINE is distinguished by its (S) configuration, which refers to the absolute configuration of the asymmetric carbon atom, making it a valuable building block in organic synthesis and medicinal chemistry.
Uses
Used in Pharmaceutical Industry:
(S)-2-O-TOLYLPIPERIDINE is used as a key intermediate for the synthesis of various pharmaceuticals and biologically active molecules. Its versatile chemical reactivity and unique stereochemistry contribute to the development of new drugs with potential therapeutic applications.
Used in Medicinal Chemistry:
(S)-2-O-TOLYLPIPERIDINE serves as a precursor in medicinal chemistry, facilitating the creation of compounds with specific pharmacological properties. Its presence in the molecular structure can influence the activity, selectivity, and potency of the resulting drug candidates.
Used in Drug Discovery:
In the realm of drug discovery, (S)-2-O-TOLYLPIPERIDINE is utilized to explore novel chemical entities with potential therapeutic benefits. Its incorporation into compound libraries aids researchers in identifying lead molecules that can be further optimized for clinical development.
Check Digit Verification of cas no
The CAS Registry Mumber 1228547-99-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,8,5,4 and 7 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1228547-99:
(9*1)+(8*2)+(7*2)+(6*8)+(5*5)+(4*4)+(3*7)+(2*9)+(1*9)=176
176 % 10 = 6
So 1228547-99-6 is a valid CAS Registry Number.
1228547-99-6Relevant articles and documents
Diversification of Unprotected Alicyclic Amines by C?H Bond Functionalization: Decarboxylative Alkylation of Transient Imines
Paul, Anirudra,Kim, Jae Hyun,Daniel, Scott D.,Seidel, Daniel
supporting information, p. 1625 - 1628 (2020/11/30)
Despite extensive efforts by many practitioners in the field, methods for the direct α-C?H bond functionalization of unprotected alicyclic amines remain rare. A new advance in this area utilizes N-lithiated alicyclic amines. These readily accessible intermediates are converted to transient imines through the action of a simple ketone oxidant, followed by alkylation with a β-ketoacid under mild conditions to provide valuable β-amino ketones with unprecedented ease. Regioselective α′-alkylation is achieved for substrates with existing α-substituents. The method is further applicable to the convenient one-pot synthesis of polycyclic dihydroquinolones through the incorporation of a SNAr step.
Efficient Routes to Chiral 2-Substituted and 2,6-Disubstituted Piperidines
Katritzky, Alan R.,Qiu, Guofang,Yang, Baozhen,Steel, Peter J.
, p. 6699 - 6703 (2007/10/03)
The syntheses of chiral 2-substituted and 2,6-disubstituted piperidines, and piperidin-2-ylphosphonates, via benzotriazole methodology are described.
