1228802-86-5

Basic information

• Product Name: 4-methyl-N-((4-nitrophenyl)(2,4,6-trimethoxyphenyl)methyl)benzenesulfonamide
• Synonyms: 4-methyl-N-((4-nitrophenyl)(2,4,6-trimethoxyphenyl)methyl)benzenesulfonamide
• CAS NO: 1228802-86-5
• Molecular Weight: 472.519
• Mol File: 1228802-86-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-methyl-N-((4-nitrophenyl)(2,4,6-trimethoxyphenyl)methyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-N-((4-nitrophenyl)(2,4,6-trimethoxyphenyl)methyl)benzenesulfonamide(1228802-86-5)
• EPA Substance Registry System: 4-methyl-N-((4-nitrophenyl)(2,4,6-trimethoxyphenyl)methyl)benzenesulfonamide(1228802-86-5)

Safety Data

• Hazardous Substances Data: 1228802-86-5(Hazardous Substances Data)

Upstream product

• 621-23-8 1,2,3-trimethoxybenzene 
• 555-16-8 4-nitrobenzaldehdye 
• 70-55-3 toluene-4-sulfonamide 
• 98-10-2 benzenesulfonamide 
• 104-88-1 4-chlorobenzaldehyde 
• 13707-46-5 N-tosyl-4-nitrobenzaldimine 
• 570-02-5 2,4,6-trimethoxybenzoic acid 

Relevant articles and documents

Synthesis method of N-diarylmethyl sulfonamide compound

The invention discloses a synthesis method of an N-diarylmethyl sulfonamide compound, and belongs to the technical field of organic synthesis intermediates. According to the synthesis method, the N-diarylmethyl sulfonamide compound is synthesized by utilizing a cascade reaction; the method specifically comprises the following steps: (1) adding an aromatic aldehyde, a sulfonamide, trimethoxybenzeneor a derivative thereof, and Lewis acid into a reaction tube according to a molar ratio of 1.0: 1.0: 1.0: 0.1, and carrying out magnetic stirring reaction at room temperature for 8-24 hours by taking1, 2-dichloroethane as a solvent; and (2) after the reaction is finished, evaporating under reduced pressure to remove most of the solvent, and carrying out column chromatography separation and purification on a residual mixed solution by using petroleum ether and ethyl acetate in a volume ratio of (1: 1)-(2: 1) as leacheate to obtain the product. The N-diarylmethyl sulfonamide compound synthesized by the method has wide application in the fields of medicines, pesticides and the like. The synthesis method disclosed by the invention has the advantages of low cost, simplicity in operation, highyield, mild conditions and the like, and has a good application prospect.

Ruthenium porphyrin catalyzed friedel-crafts type reaction of arenes with imines

Cationic ruthenium porphyrin complex was found to be an efficient catalyst for the Friedel-Crafts type reaction of arenes with imines. The use of a structurally rigid tetradentate porphyrin as the equatorial ligand and weakly coordinating axial ligand is the key to bring out the catalytic reactivity of ruthenium for the reaction.

Palladium-catalyzed decarboxylative 1,2-addition of carboxylic acids to aldehydes or imines

The first example of palladium-catalyzed decarboxylative 1,2-addition of carboxylic acids to aldehydes or imines under mild conditions is described.