1229000-10-5 Usage
Description
tert-Butyl 3-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate is a chemical compound that belongs to the class of piperidinyl benzimidazoles. It is characterized by its unique molecular structure, which features a benzimidazole core fused to a piperidine ring. tert-Butyl 3-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate is known for its potential applications in the pharmaceutical industry, particularly as a building block for the development of new drugs.
Uses
Used in Pharmaceutical Industry:
tert-Butyl 3-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate is used as a reactant in the synthesis of piperidinyl benzimidazoles, which are known for their histamine H1 receptor antagonist properties. These compounds are valuable in the development of drugs targeting the central nervous system (CNS) as they exhibit H1-antihistamine activity, making them potential candidates for the treatment of various conditions such as allergies, asthma, and other histamine-mediated disorders.
In the synthesis process, tert-Butyl 3-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate serves as a key intermediate, providing the necessary structural framework for the formation of the final drug molecule. Its unique combination of benzimidazole and piperidine moieties allows for the fine-tuning of the compound's pharmacological properties, such as potency, selectivity, and bioavailability, which are crucial factors in the development of effective therapeutic agents.
Furthermore, the use of tert-Butyl 3-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate in the pharmaceutical industry highlights the importance of chemical diversity and innovation in drug discovery. By exploring novel chemical structures and their potential applications, researchers can identify new therapeutic targets and develop more effective treatments for a wide range of medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1229000-10-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,9,0,0 and 0 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1229000-10:
(9*1)+(8*2)+(7*2)+(6*9)+(5*0)+(4*0)+(3*0)+(2*1)+(1*0)=95
95 % 10 = 5
So 1229000-10-5 is a valid CAS Registry Number.
1229000-10-5Relevant articles and documents
SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE
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Paragraph 0198, (2016/03/13)
The present disclosure is generally directed to compositions useful in the inhibition of MetRS and methods for treating diseases that are ameliorated by the inhibition of MetRS.
Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: Identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H1-antihistamines for insomnia
Ravula, Satheesh Babu,Yu, Jinghua,Tran, Joe A.,Arellano, Melissa,Tucci, Fabio C.,Moree, Wilna J.,Li, Bin-Feng,Petroski, Robert E.,Wen, Jianyun,Malany, Siobhan,Hoare, Samuel R.J.,Madan, Ajay,Crowe, Paul D.,Beaton, Graham
scheme or table, p. 421 - 426 (2012/02/04)
The structure-activity relationships of 2-(piperidin-3-yl)-1H- benzimidazoles, 2-morpholine and 2-thiomorpholin-2-yl-1H-benzimidazoles are described. In the lead optimization process, the pKa and/or log P of benzimidazole analogs were reduced e
