123148-66-3

Basic information

• Product Name: 4-Pyridinemethanol,2-methoxy-(9CI)
• Synonyms: 4-Pyridinemethanol,2-methoxy-(9CI);(2-methoxy-4-pyridinyl)methanol;2-Methoxypyridine-4-metha...;2-Methoxypyridine-4-Methanol;2-Methoxypyridin-4-Methanol;2-Methoxy-4-PyridineMethanol;4-PyridineMethanol,2-Methoxy-
• CAS NO: 123148-66-3
• Molecular Formula: C₇H₉NO₂
• Molecular Weight: 139.16
• Product Categories: PYRIDINE
• Mol File: 123148-66-3.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 259.2 °C at 760 mmHg
• Flash Point: 110.6 °C
• Appearance: /
• Density: 1.155 g/cm³
• Vapor Pressure: 0.0067mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-Pyridinemethanol,2-methoxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridinemethanol,2-methoxy-(9CI)(123148-66-3)
• EPA Substance Registry System: 4-Pyridinemethanol,2-methoxy-(9CI)(123148-66-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 123148-66-3(Hazardous Substances Data)

Usage

General Description

4-Pyridinemethanol,2-methoxy-(9CI) is a chemical compound that belongs to the pyridine family. It has the molecular formula C7H9NO2 and is also known by its IUPAC name 2-methoxy-4-(pyridin-4-yl)methanol. 4-Pyridinemethanol,2-methoxy-(9CI) is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs and pharmaceuticals. It is also utilized in organic synthesis and as a building block for the production of other chemical compounds. 4-Pyridinemethanol,2-methoxy-(9CI) has potential applications in the development of new medicines and medical treatments due to its unique chemical properties. Overall, this chemical compound plays a crucial role in the pharmaceutical and chemical industries.

InChI:InChI=1/C7H9NO2/c1-10-7-4-6(5-9)2-3-8-7/h2-4,9H,5H2,1H3

Upstream product

• 26156-51-4 methyl 2-methoxyisonicotinate 
• 100704-10-7 (2-chloropyridin-4-yl)methanol 
• 124-41-4 sodium methylate 
• 33252-30-1 2-chloro-4-pyridinenitrile 
• 72716-86-0 4-cyano-2-methoxypyridine 
• 6313-54-8 2-chloroisonicotinic acid, 
• 105596-63-2 2-methoxy-isonicotinic acid 
• 58481-11-1 methyl 2-chloroisonicotinate 
• 22282-72-0 2-hydroxyisonicotinic acid 
• 754218-84-3 2-methoxypyridine-4-methyl methoxymethyl ether 
• 105596-61-0 ethyl 2-methoxy-pyridine-4-carboxylate 

Downstream Products

• 72716-87-1 2-methoxypyridine-4-carboxaldehyde 
• 355013-79-5 4-(chloromethyl)-2-methoxypyridine 
• 764708-27-2 2-(2-methoxypyridin-4-yl)ethylamine 
• 1395552-82-5 2-(4-bromo-3-fluorophenyl)-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-methylpyrimidin-4-amine 
• 764708-39-6 C₁₈H₁₆BrFN₄O 
• 764708-28-3 2-(4-bromo-2,5-difluorophenyl)-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-methylpyrimidin-4-amine 
• 1395552-89-2 2-(4-chloro-2,5-difluorophenyl)-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-methylpyrimidin-4-amine 
• 1395552-94-9 2-(4-chloro-2,5-difluorophenyl)-6-ethyl-N-[2-(2-methoxypyridin-4-yl)ethyl]pyrimidin-4-amine 
• 764708-29-4 4-(2-{[2-(4-Bromo-2,5-difluorophenyl)-6-methylpyrimidin-4-yl]amino}ethyl)pyridin-2(1H)-one 
• 795266-61-4 4-(2-{[2-(4-chloro-2,5-difluorophenyl)-6-ethylpyrimidin-4-yl]amino}ethyl)pyridin-2(1H)-one 
• 1361225-30-0 1,1,1,3,3,3-hexafluoro-2-(4-(2-((2-methoxy-4-pyridinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol 
• 1361225-28-6 2-((2-methoxy-4-pyridinyl)methyl)piperazine 
• 1361222-20-9 ethyl N-(diphenylmethylidene)-3-(6-methoxy-4-pyridinyl)alaninate 

Relevant articles and documents

Discovery of a Class of Potent and Selective Non-competitive Sentrin-Specific Protease 1 Inhibitors

Sentrin-specific proteases (SENPs) are responsible for the maturation of small ubiquitin-like modifiers (SUMOs) and the deconjugation of SUMOs from their substrate proteins. Studies on prostate cancer revealed an overexpression of SENP1, which promotes prostate cancer progression as well as metastasis. Therefore, SENP1 has been identified as a novel drug target against prostate cancer. Herein, we report the discovery and biological evaluation of potent and selective SENP1 inhibitors. A structure-activity relationship (SAR) of the newly identified pyridone scaffold revealed allosteric inhibitors with very attractive in vitro ADMET properties regarding plasma binding and plasma stability for this challenging target. This study also emphasizes the importance of biochemical mode of inhibition studies for de novo designed inhibitors.

N-methyl tetrahydroquinoline M1 receptor positive allosteric modulators

The present invention is directed to N-methyl tetrahydroquinoline compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.

COMPOUND OF CAMPTOTHECIN AND PREPARATION AND USE THEREOF

The present disclosure relates to a compound of formula I, a pharmaceutical composition thereof and the use thereof as an anti-tumor drug.