1233094-95-5

Basic information

• Product Name: 7-BroMo-2-(Methylthio)pyrrolo[1,2-f][1,2,4]triazine
• Synonyms: 7-BroMo-2-(Methylthio)pyrrolo[1,2-f][1,2,4]triazine;7-broMo-2-(Methylthio)pyrrolo[2,1-f][1,2,4]triazine;7-bromo-2-(methylsulfanyl)pyrrolo[2,1-f][1,2,4]triazine
• CAS NO: 1233094-95-5
• Molecular Formula: C₇H₆BrN₃S
• Molecular Weight: 244.12
• Mol File: 1233094-95-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 7-BroMo-2-(Methylthio)pyrrolo[1,2-f][1,2,4]triazine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-BroMo-2-(Methylthio)pyrrolo[1,2-f][1,2,4]triazine(1233094-95-5)
• EPA Substance Registry System: 7-BroMo-2-(Methylthio)pyrrolo[1,2-f][1,2,4]triazine(1233094-95-5)

Safety Data

• Hazardous Substances Data: 1233094-95-5(Hazardous Substances Data)

Usage

General Description

7-Bromo-2-(methylthio)pyrrolo[1,2-f][1,2,4]triazine, also known as BMTPT, is a chemical compound with the molecular formula C6H5BrN4S. It is a heterocyclic compound that contains a bromine atom, a methylthio group, and a pyrrolo-triazine ring system. BMTPT is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential antitumor and antiviral properties. Additionally, BMTPT has been investigated as a building block for the construction of various organic compounds. While it has potential utility in various applications, BMTPT is not widely used in commercial products and its safety and environmental impact have not been extensively studied.

Upstream product

• 1232815-48-3 1-(3-benzoyl-thioureido)-1H-pyrrole-2-carboxylic acid methyl ester 
• 1232815-49-4 2-thioxo-2,3-dihydro-1H-pyrrolo[2,1-f][1,2,4]triazin-4-one 
• 1232815-50-7 2-(methylsulfanyl)-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-4-one 
• 1120214-78-9 4-chloro-2-methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazine 
• 1232815-51-8 7-bromo-4-chloro-2-(methylsulfanyl)pyrrolo[2,1-f][1,2,4]triazine 

Downstream Products

• 1232815-55-2 2-methylsulfinyl-7-phenyl-pyrrolo[2,1-f][1,2,4]triazine 
• 1318629-62-7 (7-bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-(3,4,5-trimethoxy-phenyl)-amine 
• 1232397-16-8 (7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-(3,4,5-trimethoxy-phenyl)amine 
• 1318629-63-8 7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-ol 

Relevant articles and documents

PYRROLOTRIAZINE COMPOUNDS AND METHODS OF INHIBITING TAM KINASES

Described herein are compounds, methods of making such compounds, pharmaceutical compositions, and medicaments comprising such compounds, and methods of using such compounds to treat cancer. (II), or a pharmaceutically acceptable salt thereof, wherein: R1 is pyridin-3-yl, pyridin-4-yl, pyrazol-4-yl, cyclohexyl, or 8-azabicyclo[3.2.1]oct-2- ene-3-yl, wherein R1 is optionally substituted with up to four independently selected substituents; R2 is cyclohexyl substituted with hydroxy and optionally substituted with one or two additional substituents independently selected from C1-C4 alkyl and fluoro, or is 4,5,6,7- tetrahydro-lH-indazolyl optionally substituted with one to three substituents independently selected from C1-C4 alkyl and fluoro; and R3 is -C3-C8 alkyl, -(C2-C6 alkylene)-0-(C1-C6 alkyl), C3-C6 cycloalkyl, or -(C2-C6 alkylene)-C3-C6 cycloalkyl, wherein R3 is optionally substituted with 1-5 substituents inde endentl selected from deuterium, halo, and -OH.

PYRROLOTRIAZINE INHIBITORS OF IRAK4 ACTIVITY

The present invention relates to pyrrolotriazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.