123333-23-3Relevant articles and documents
Iridium/f-Amphox-Catalyzed Asymmetric Hydrogenation of Styrylglyoxylamides
Wang, Simin,Yu, Yuena,Wen, Jialin,Zhang, Xumu
supporting information, p. 2203 - 2207 (2018/09/29)
We report an iridium-catalyzed asymmetric hydrogenation reaction for the preparation of chiral homophenylalanine derivatives. Catalyzed by an iridium/f-amphox complex, the asymmetric hydrogenation of styrylglyoxylamides was conducted smoothly with turnover numbers of up to 10,000 and up to 98% ee. This method was successfully applied in a synthesis of a fragment of benazepril, a drug used for the treatment of high blood pressure.
An efficient synthesis of novel hexahydropyrido[2,3-d]pyrimidine derivatives from (arylmethylidene)pyruvic acids =(3E)-4-aryl-2-oxobut-3-enoic acids in aqueous media
Balalaie, Saeed,Abdolmohammadi, Shahrzad,Soleimanifard, Bita
body text, p. 932 - 936 (2009/08/14)
A series of new hexahydropyrido[2,3-d]pyrimidine derivatives 3 were synthesized by the cyclo-condensation reaction of (arylmethylidene)pyruvic acids (=(3E)-4-aryl-2-oxobut-3-enoic acids) 1 and 6-aminouracils (=6-aminopyrimidine- 2,4(1H,3H)-diones) 2 in H
(E)-4-(α-Halo-p-tolyl)-2-oxo-3-butenoic Acids Inhibit Yeast Pyruvate Decarboxylase by a Diversity of Mechanisms: Multiple Fate for the Thiamin-Bound Enamine Intermediate
Annan, Nikoi,Paris, Richard,Jordan, Frank
, p. 8895 - 8901 (2007/10/02)
(E)-4-(p-Tolyl)-2-oxo-3-butenoic acid and its α-(bromomethyl) and α-(chloromethyl) derivatives have been synthesized, and their interaction with brewers' yeast pyruvate decarboxylase was evaluated.The p-tolyl compound was found to be a slow substrate.The