1233497-39-6

Basic information

• Product Name: C₂₆H₂₃F₃N₄O₃S
• Synonyms: C₂₆H₂₃F₃N₄O₃S
• CAS NO: 1233497-39-6
• Molecular Weight: 528.555
• Mol File: 1233497-39-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₂₃F₃N₄O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₂₃F₃N₄O₃S(1233497-39-6)
• EPA Substance Registry System: C₂₆H₂₃F₃N₄O₃S(1233497-39-6)

Safety Data

• Hazardous Substances Data: 1233497-39-6(Hazardous Substances Data)

Upstream product

• 1233497-38-5 (2-{3-oxo-3-[4-(5-p-tolyl-3-trifluoromethyl-pyrazol-1-yl)-benzenesulfonylamino]-propyl}-phenyl)-carbamic acid tert-butyl ester 

Downstream Products

• 553-03-7 3,4-dihydro-2(1H)-quinolone 
• 169590-42-5 4-[5-(4-(methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulphonamide 
• 1233497-36-3 C₃₇H₃₄F₃N₅O₆S 
• 1233497-32-9 2-hydroxy-5-(2-{3-oxo-3-[4-(5-p-tolyl-3-trifluoromethyl-pyrazol-1-yl)-benzenesulfonylamino]-propyl}-phenylazo)benzoic acid 

Relevant articles and documents

A double prodrug system for colon targeting of benzenesulfonamide COX-2 inhibitors

The design, synthesis and delivery potential of a new type of benzenesulfonamide cyclo-oxygenase-2 (COX-2) inhibitor prodrug is investigated using celecoxib. The approach involves a double prodrug that is activated first by azoreductases and then by cyclization triggering drug release. We studied the intramolecular aminolysis of the acylsulfonamide. The cyclization was surprisingly rapid at physiological pH and very fast at pH 5. The prodrug is activated specifically under conditions found in the colon but highly stable in the presence of human and rodent intestinal extracts. Finally, the prototype with celecoxib was transported much more slowly in the Caco-2 transepithelial model than the parent. The design therefore shows significant promise for the site specific delivery of benzenesulfonamide COX-2 inhibitors to the colon.