1235491-92-5

Basic information

• Product Name: 4-chloro-1-(2-methoxy-4-nitrophenyl)-1H-imidazole
• Synonyms: 4-chloro-1-(2-methoxy-4-nitrophenyl)-1H-imidazole
• CAS NO: 1235491-92-5
• Molecular Weight: 253.645
• Mol File: 1235491-92-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4-chloro-1-(2-methoxy-4-nitrophenyl)-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-1-(2-methoxy-4-nitrophenyl)-1H-imidazole(1235491-92-5)
• EPA Substance Registry System: 4-chloro-1-(2-methoxy-4-nitrophenyl)-1H-imidazole(1235491-92-5)

Safety Data

• Hazardous Substances Data: 1235491-92-5(Hazardous Substances Data)

Upstream product

• 1009-36-5 2-chloro-5-nitroanisole 
• 15965-31-8 4-chloro-1H-imidazole 

Downstream Products

• 1235491-93-6 4-(4-chloro-1H-imidazol-1-yl)-3-methoxybenzenamine 
• 1263865-09-3 (R)-N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-7-(4-fluorophenyl)-N₄-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine 
• 1263865-08-2 (S)-N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-7-(4-fluorophenyl)-N₄-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine 
• 1263865-07-1 N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-7-(4-fluorophenyl)-N₄-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine 
• 1263865-06-0 N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N₄-isopropyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine 
• 1263865-05-9 N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N₄-cyclobutyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine 
• 1263865-04-8 N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N₄-cyclopropyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine 
• 1263865-03-7 (R)-N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N₄-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine 
• 1263865-02-6 (S)-N²-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N⁴-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine 
• 1263865-01-5 N²-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N⁴-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine 

Relevant articles and documents

Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481

A triazine hit identified from a screen of the BMS compound collection was optimized for potency, in vivo activity, and off-target profile to produce the bicyclic pyrimidine γ-secretase modulator BMS-932481. The compound showed robust reductions of Aβsub

FUSED MORPHOLINOPYRIMIDINES AND METHODS OF USE THEREOF

The present invention relates to Fused Morpholinopyrimidines, pharmaceutical compositions comprising an effective amount of a Fused Morpholinopyrimidine and methods for using a Fused Morpholinopyrimidine in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of a Fused Morpholinopyrimidine.

Synthesis and characterization of new N-(4-(4-chloro-1H-imidazol-1-yl)-3- methoxyphenyl)amide/sulfonamide derivatives as possible antimicrobial and antitubercular agents

In this paper we report the SAR studies of a series of N-(4-(4-chloro-1H- imidazol-1-yl)-3-methoxyphenyl)amide and N-(4-(4-chloro-1H-imidazol-1-yl)-3- methoxyphenyl)sulfonamide derivatives 6(a-o) and 7(a-o), were synthesized in good yields and characterized by 1H NMR, 13C NMR and mass spectral analyses. The preparation of the key intermediate highlights an optimized palladium catalyzed (Pd2(dba)3/RuPhos) Buchwald cross-coupling of intermediate 2 and 3. The newly synthesized compounds were evaluated for their in vitro antibacterial activity against Staphylococcus aureus, (Gram-positive), Escherichia coli and Klebsiella pneumoniae (Gram-negative), antifungal activity against Candida albicans, Aspergillus flavus and Rhizopus sp. and antitubercular activity against Mycobacterium tuberculosis H37Rv, Mycobacterium smegmatis, Mycobacterium fortuitum and MDR-TB strains. The synthesized compounds displayed interesting antimicrobial activity. The compounds 7d, 7f, 7h and 7n displayed significant activity against Mycobacterium tuberculosis H37Rv strain.