123594-00-3

Basic information

• Product Name: 5-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
• CAS NO: 123594-00-3
• Molecular Formula: C₉H₁₀FN
• Molecular Weight: 151.1808032
• Mol File: 123594-00-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(123594-00-3)
• EPA Substance Registry System: 5-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(123594-00-3)

Safety Data

• Hazardous Substances Data: 123594-00-3(Hazardous Substances Data)

Upstream product

• 52721-69-4 [2-(2-fluorophenyl)ethyl]amine 
• 123594-08-1 N-(carbobenzyloxy)-5-fluoro-1,2,3,4-tetrahydroisoquinoline 
• 123594-07-0 5-amino-3,4-dihydroisoquinoline-2(H)-carboxylic acid benzyl ester ester 
• 123594-06-9 5-Nitro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester 
• 230301-83-4 5-fluoro-3,4-dihydro-2H-isoquinolin-1-one 
• 1438253-33-8 1-bromo-3-fluoro-2-(2-nitroethyl)benzene 
• 41959-45-9 5-nitro-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Intramolecular Reductive Cyclization of o-Nitroarenes via Biradical Recombination

A visible-light-induced/thiourea-mediated intramolecular cyclization of o-nitroarenes under mild conditions is realized for the first time, which provides an efficient and environmentally friendly way to access pharmaceutical relevant quinazolinone derivatives. The reaction can be easily extended to gram level by using a continuous-flow setup with high efficiency. Mechanistic investigation including control experiments, transient fluorescence, UV-vis spectra, and DFT calculations suggests that the formation of active biradical intermediates via intramolecular single electron transfer (SET) is key stage in the catalytic cycle.

Catalyst-free cyclization of anthranils and cyclic amines: One-step synthesis of rutaecarpine

An efficient synthesis of a variety of quinazolinone derivatives via a direct cyclization reaction between commercially available anthranils and cyclic amines is described. The developed transformation proceeds with the merits of high step- and atom-efficiency, a broad substrate scope, and good to excellent yields, without additional catalysts, and offers a practical way for the preparation of rutaecarpine and its derivatives with structural diversity.

NOVEL TETRAHYDROISOQUINOLINES AND TERAHYDRONAPHTHYRIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The present invention provides novel compounds having the general formula (I): wherein R1, R 2, R 3, U, V, W, X and Y are as described herein, compositions including the compounds and methods of using the compounds.