1236074-94-4

Basic information

• Product Name: trichoderin A
• Synonyms: trichoderin A
• CAS NO: 1236074-94-4
• Molecular Weight: 1163.59
• Mol File: 1236074-94-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: trichoderin A(CAS DataBase Reference)
• NIST Chemistry Reference: trichoderin A(1236074-94-4)
• EPA Substance Registry System: trichoderin A(1236074-94-4)

Safety Data

• Hazardous Substances Data: 1236074-94-4(Hazardous Substances Data)

Upstream product

• 68858-20-8 Fmoc-Val-OH 
• 1408287-02-4 (2S,4S,6S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-6-hydroxy-4-methyl-8-oxodecanoic acid 
• 71989-31-6 Fmoc-Pro-OH 
• 74235-20-4 (R)-(-)-2-methyldecanoic acid 
• 71989-23-6 Fmoc-Ile-OH 
• 94744-50-0 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-α-aminoisobutyric acid 

Downstream Products

• 128425-02-5 L-FDAA-L-Pro 
• 128425-14-9 L-FDAA-D-Pro 
• 89131-11-3 dabsyl-L-valine 
• 89131-09-9 C₁₉H₂₂N₄O₄S 
• 89131-13-5 C₂₀H₂₆N₄O₄S 
• 72-18-4 L-valine 
• 73-32-5 L-isoleucine 
• 62-57-7 2-Aminoisobutyric acid 
• 147-85-3 L-proline 

Relevant articles and documents

Total Synthesis and Stereochemical Revision of the Anti-Tuberculosis Peptaibol Trichoderin A

The first total synthesis of the postulated structure of the aminolipopeptide trichoderin A and its epimer are reported. A late-stage solution phase C-terminal coupling was employed to introduce the C-terminal aminoalcohol moiety. This methodology provides a foundation to prepare analogues of trichoderin A to establish a structure-activity relationship. NMR spectroscopic analysis established that the C-6 position of the 2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid (AHMOD) residue in trichoderin A possesses an (R)-configuration as opposed to the originally proposed (S)-configuration.