1236357-64-4 Usage
Description
1-(4-Bromo-phenyl)-cyclopentanecarboxylic acid methyl ester is a chemical compound characterized by the molecular formula C12H13BrO2. It is a methyl ester derivative of a carboxylic acid, featuring a bromo-substituted phenyl group and a cyclopentane ring. 1-(4-BroMo-phenyl)-cyclopentanecarboxylic acid Methyl ester is known for its utility in organic synthesis and medicinal chemistry research, where it serves as a valuable building block or intermediate in the creation of various pharmaceuticals and bioactive compounds. Its unique structural features also lend it potential for use in the development of new drugs and agrochemicals.
Uses
Used in Organic Synthesis:
1-(4-Bromo-phenyl)-cyclopentanecarboxylic acid methyl ester is used as a building block in the synthesis of pharmaceuticals and bioactive compounds, contributing to the development of novel chemical entities with potential therapeutic applications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1-(4-Bromo-phenyl)-cyclopentanecarboxylic acid methyl ester is utilized as an intermediate for the synthesis of complex molecular structures with potential medicinal properties, aiding in the advancement of drug discovery.
Used in Chemical Reactions:
1-(4-BroMo-phenyl)-cyclopentanecarboxylic acid Methyl ester is employed as a reagent in various chemical reactions, such as Suzuki-Miyaura coupling, Heck coupling, and Sonogashira coupling, facilitating the formation of new carbon-carbon and carbon-heteroatom bonds, which are crucial for the synthesis of a wide range of organic compounds.
Used in Drug Development:
Due to its unique structural features, 1-(4-Bromo-phenyl)-cyclopentanecarboxylic acid methyl ester may have potential applications in the development of new drugs, particularly in the areas of pharmaceuticals and agrochemicals, where its properties can be harnessed to create innovative and effective products.
Used in Agrochemical Development:
1-(4-BroMo-phenyl)-cyclopentanecarboxylic acid Methyl ester's structural attributes also make it a candidate for use in the development of new agrochemicals, where it could contribute to the creation of novel products with enhanced efficacy and selectivity in agricultural applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1236357-64-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,3,6,3,5 and 7 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1236357-64:
(9*1)+(8*2)+(7*3)+(6*6)+(5*3)+(4*5)+(3*7)+(2*6)+(1*4)=154
154 % 10 = 4
So 1236357-64-4 is a valid CAS Registry Number.
1236357-64-4Relevant articles and documents
Achiral Derivatives of Hydroxamate AR-42 Potently Inhibit Class i HDAC Enzymes and Cancer Cell Proliferation
Tng, Jiahui,Lim, Junxian,Wu, Kai-Chen,Lucke, Andrew J.,Xu, Weijun,Reid, Robert C.,Fairlie, David P.
supporting information, p. 5956 - 5971 (2020/06/05)
AR-42 is an orally active inhibitor of histone deacetylases (HDACs) in clinical trials for multiple myeloma, leukemia, and lymphoma. It has few hydrogen bond donors and acceptors but is a chiral 2-arylbutyrate and potentially prone to racemization. We report achiral AR-42 analogues incorporating a cycloalkyl group linked via a quaternary carbon atom, with up to 40-fold increased potency against human class I HDACs (e.g., JT86, IC50 0.7 nM, HDAC1), 25-fold increased cytotoxicity against five human cancer cell lines, and up to 70-fold less toxicity in normal human cells. JT86 was ninefold more potent than racAR-42 in promoting accumulation of acetylated histone H4 in MM96L melanoma cells. Molecular modeling and structure-activity relationships support binding to HDAC1 with tetrahydropyran acting as a hydrophobic shield from water at the enzyme surface. Such potent inhibitors of class I HDACs may show benefits in diseases (cancers, parasitic infections, inflammatory conditions) where AR-42 is active.
DIHYDROPYRIMIDINE COMPOUNDS AND USES THEREOF IN MEDICINE
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Paragraph 00307, (2019/01/17)
Provided herein are a dihydropyrimidine compound and a pharmaceutical application thereof, especially the application used for treating and preventing HBV diseases. Specifically, provided herein is a compound having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein the variables of the formulas are as defined in the specification. Also provided herein is use of the compound having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof as a medicine, especially for treating and preventing HBV diseases.
