1239319-82-4

Basic information

• Product Name: 2-AMino-7-Boc-7-azaspiro[...
• Synonyms: 2-AMino-7-Boc-7-azaspiro[...;2-AMino-7-Boc-7-azaspiro[3.5]nonane;2-AMino-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester;tert-Butyl 2-amino-7-azaspiro[3.5]nonane-7-carboxylate
• CAS NO: 1239319-82-4
• Molecular Formula: C₁₃H₂₄N₂O₂
• Molecular Weight: 240.34186
• Mol File: 1239319-82-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 336.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.08±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10?+-.0.20(Predicted)
• CAS DataBase Reference: 2-AMino-7-Boc-7-azaspiro[...(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMino-7-Boc-7-azaspiro[...(1239319-82-4)
• EPA Substance Registry System: 2-AMino-7-Boc-7-azaspiro[...(1239319-82-4)

Safety Data

• Hazardous Substances Data: 1239319-82-4(Hazardous Substances Data)

Usage

General Description

The chemical "2-Amino-7-Boc-7-azaspiro[4.4]nonane" is a compound with potential pharmaceutical applications. It is a spirocyclic scaffold that can be utilized in drug discovery and design due to its unique structural and physicochemical properties. The presence of an amino group and a Boc protecting group makes it a versatile building block for the synthesis of various bioactive molecules. Its spirocyclic nature also contributes to its potential biological activity and drug-like properties. Overall, this compound has the potential to be a valuable tool in the development of new therapeutic agents.

Upstream product

• 614729-59-8 2-((methylsulfonyl)oxy)-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester 
• 1239319-81-3 2-azido-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester 
• 240401-28-9 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester 
• 159635-49-1 tert-butyl 4-methylidenepiperidine-1-carboxylate 
• 1239320-24-1 tert-butyl 2-(hydroxyimino)-7-azaspiro[3.5]nonane-7-carboxylate 
• 203661-69-2 tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate 

Downstream Products

• 1239319-83-5 tert-Butyl 2-(4-nitrophenoxycarbonylamino)-7-azaspiro[3.5]nonane-7-carboxylate 
• 1239319-64-2 3-carbamoylisoxazol-5-ylmethyl{7-[5-(4-fluorophenyl)pyridin-2-yl]-7-azaspiro[3.5]non-2-yl}carbamate 
• 1417838-14-2 C₂₆H₃₂F₃N₇O₂ 
• 1417838-02-8 C₂₆H₃₂F₃N₇O₂ 
• 1313732-91-0 (7-aza-spiro[3.5]non-2-yl)-[(S)-6,7-dimethyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-amine 
• 1313732-90-9 7-[(S)-6,7-dimethyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-ylamine 
• 1313732-59-0 7-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-ylamine 
• 1313732-60-3 (7-aza-spiro[3.5]non-2-yl)-[6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1 ,2,3a,4,6-pentaaza-cyclopenta[a]naphthalen-5-yl]-amine 
• 1313802-10-6 7-[9-methyl-3-(3-trifluoromethoxy-phenyl)-8,9-dihydro-7H-6-oxa-1,2,3a,4,9-pentaaza-cyclopenta[a]naphthalen-5-yl]-7-aza-spiro[3.5]non-2-ylamine 
• 1313802-09-3 (7-aza-spiro[3.5]non-2-yl)-[9-methyl-3-(3-trifluoromethoxy-phenyl)-8,9-dihydro-7H-6-oxa-1,2,3a,4,9-pentaaza-cyclopenta[a]naphthalen-5-yl]-amine 

Relevant articles and documents

1-azaspirocycle compound, and preparation method and applications thereof

The invention discloses a 1-azaspirocycle compound, and preparation method and applications thereof, and belongs to the field of pharmaceutical chemistry. The 1-azaspirocycle compound with a structurerepresented by formula I, or a pharmaceutically acceptable salt or a stereisomer or a solvate or a prodrug thereof is capable of realzing combination with Autotaxin, can be taken as an Autotaxin inhibitor, and can be used for prevention and treatment of diseases with Autotaxin expression increasing pathological characteristics such as cancer and fibrosis diseases especially pulmonary fibrosis andhepatic fibrosis, metabolic diseases, myelodysplastic syndrome, cardiovascular diseases, autoimmune diseases, inflammation, neurological diseasses, or pain. Compared with single component inhibitors,the 1-azaspirocycle compound and the derivatives possesses following advantages: blocking and interfacing at the upsteam of a plurality of key signal channels are realized, tumor cell growth and transfer are relieved or dalyed, early caused drug resistance is avoided, and novel means are provided for treatment of tumor cells.