1239589-54-8

Basic information

• Product Name: C₁₉H₂₆N₂O₄
• Synonyms: C₁₉H₂₆N₂O₄
• CAS NO: 1239589-54-8
• Molecular Weight: 346.426
• Mol File: 1239589-54-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₆N₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₆N₂O₄(1239589-54-8)
• EPA Substance Registry System: C₁₉H₂₆N₂O₄(1239589-54-8)

Safety Data

• Hazardous Substances Data: 1239589-54-8(Hazardous Substances Data)

Upstream product

• 1239320-12-7 tert-butyl 6-azido-2-azaspiro[3.3]heptane-2-carboxylate 
• 1211526-53-2 2-[(tert-butoxy)carbonyl]-2-azaspiro[3.3]heptane-6-carboxylic acid 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1211586-09-2 6-amino-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester 

Relevant articles and documents

ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE-1 (ENPP1) INHIBITORS AND USES THEREOF

The present invention discloses compounds useful in treatment of conditions associated with dysfunction of ectonucleotide pyrophosphatase / phosphodiesterase-1 (ENPP1) enzyme. Specifically, the present invention discloses compound of formula (J) which exhibit inhibitory activity against ENPP1. Method of treating conditions associated with over-expression of ENPP1 gene with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.

Cyclobutane-derived diamines: Synthesis and molecular structure

Cyclobutane diamines (i.e., cis- and trans-1,3-diaminocyclobutane, 6-amino-3-azaspiro[3.3]heptane, and 3,6-diaminospiro[3.3]heptane) are considered as promising sterically constrained diamine building blocks for drug discovery. An approach to the syntheses of their Boc-monoprotected derivatives has been developed aimed at the preparation of multigram amounts of the compounds. These novel synthetic schemes exploit classical malonate alkylation chemistry for the construction of cyclobutane rings. The conformational preferences of the cyclobutane diamine derivatives have been evaluated by X-ray diffraction and compared with the literature data on sterically constrained diamines, which are among the constituents of commercially available drugs.