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1239703-36-6

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1239703-36-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1239703-36-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,3,9,7,0 and 3 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1239703-36:
(9*1)+(8*2)+(7*3)+(6*9)+(5*7)+(4*0)+(3*3)+(2*3)+(1*6)=156
156 % 10 = 6
So 1239703-36-6 is a valid CAS Registry Number.

1239703-36-6Relevant articles and documents

Development of dual functional SPECT/fluorescent probes for imaging cerebral β-amyloid plaques

Ono, Masahiro,Ishikawa, Manami,Kimura, Hiroyuki,Hayashi, Shun,Matsumura, Kenji,Watanabe, Hiroyuki,Shimizu, Yoichi,Cheng, Yan,Cui, Mengchao,Kawashima, Hidekazu,Saji, Hideo

supporting information; experimental part, p. 3885 - 3888 (2010/09/03)

The imaging of β-amyloid (Aβ) aggregates in the brain may lead to the early detection of Alzheimer's disease (AD) and monitoring of the progression and effectiveness of treatment. The purpose of this study was to develop dual modality SPECT and fluorescent probes based on boron dipyrromethane (BODIPY) as a core structure. We designed and synthesized an 125I-labeled derivative of BODIPY (BODIPY7). BODIPY7 had a K i value of 108 nM for Aβ(1-42) aggregates and exhibited peaks of absorption/emission at 606/613 nm. It detected Aβ plaques in sections of brain tissue from an animal model of AD and displayed low uptake in the brain and high uptake in the liver in normal mice. Although additional modifications of the BODIPY scaffold are necessary to improve brain uptake, these results should aid the development of dual functional SPECT/fluorescent probes for the imaging of Aβ plaques in the brain.

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