124072-84-0

Basic information

• Product Name: (S)-HEXAHYDRO-PYRROLO[1,2-A]PYRAZIN-4-ONE
• Synonyms: (S)-HEXAHYDRO-PYRROLO[1,2-A]PYRAZIN-4-ONE;(8aS)-hexahydro-Pyrrolo[1,2-a]pyrazin-4(1H)-one;(S)-hexahydropyrrolo[1,2-a]pyrazin-4(1H)-one
• CAS NO: 124072-84-0
• Molecular Formula: C₇H₁₂N₂O
• Molecular Weight: 140.185
• Mol File: 124072-84-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 284.4±29.0℃ (760 Torr)
• Flash Point: 125.8±24.3℃
• Appearance: /
• Density: 1.17±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-HEXAHYDRO-PYRROLO[1,2-A]PYRAZIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-HEXAHYDRO-PYRROLO[1,2-A]PYRAZIN-4-ONE(124072-84-0)
• EPA Substance Registry System: (S)-HEXAHYDRO-PYRROLO[1,2-A]PYRAZIN-4-ONE(124072-84-0)

Safety Data

• Hazardous Substances Data: 124072-84-0(Hazardous Substances Data)

Usage

Description

(S)-HEXAHYDRO-PYRROLO[1,2-A]PYRAZIN-4-ONE, also known as GRN-529, is a chemical compound that functions as a selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5). It is recognized for its potential therapeutic applications in the treatment of neurological and psychiatric disorders due to its ability to modulate glutamate signaling in the brain, which can positively impact synaptic plasticity, neurotransmission, and neuronal function.

Uses

Used in Pharmaceutical Industry:
(S)-HEXAHYDRO-PYRROLO[1,2-A]PYRAZIN-4-ONE is used as a therapeutic agent for the treatment of neurological and psychiatric disorders. Its application is based on its ability to block the activity of mGluR5, which is implicated in the pathophysiology of these conditions.
Used in Fragile X Syndrome Treatment:
In the context of Fragile X syndrome, (S)-HEXAHYDRO-PYRROLO[1,2-A]PYRAZIN-4-ONE is used as a potential treatment to alleviate symptoms associated with this genetic disorder, given its role in modulating glutamate signaling, which is disrupted in Fragile X syndrome.
Used in Autism Treatment:
For autism, (S)-HEXAHYDRO-PYRROLO[1,2-A]PYRAZIN-4-ONE is considered as a therapeutic intervention aimed at improving core symptoms and cognitive functions by targeting the mGluR5 receptor, which is thought to be involved in the disorder's underlying neurobiology.
Used in Addiction Treatment:
In addiction treatment, (S)-HEXAHYDRO-PYRROLO[1,2-A]PYRAZIN-4-ONE is used as a pharmacological agent to potentially reduce cravings and compulsive behaviors associated with substance use disorders by modulating the glutamatergic system, which is implicated in the addiction process.
Research on (S)-HEXAHYDRO-PYRROLO[1,2-A]PYRAZIN-4-ONE is ongoing to further explore its potential as a novel pharmacological agent for the treatment of these and other related conditions, highlighting its significance in the development of new therapeutic strategies for various neurological and psychiatric disorders.

Relevant articles and documents

New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same

A compound of the formula: STR1 wherein R1 is lower alkyl optionally substituted with a substituent selected from the group consisting of acyl, hydroxy, lower alkoxy, aryl, lower alkylthio and a group of the formula: STR2 in which R5 is hydrogen or acyl and R6 is hydrogen or lower alkyl; aryl; or amino optionally substituted with substituent(s) selected from the group consisting of lower alkyl and acyl; and R2 is hydrogen or lower alkyl; or R1 and R2 are taken together with the attached nitrogen atom to form a heterocyclic group optionally substituted with substituent(s) selected from the group consisting of lower alkyl, hydroxy(lower )alkyl, lower alkoxy(lower)alkyl, acyl(lower)alkyl, oxo and acyl; R3 is hydrogen or lower alkyl; and R4 is lower alkyl; and its pharmaceutically acceptable salt, processes for the preparation thereof and pharmaceutical composition comprising the same.