124095-27-8

Basic information

• Product Name: (R)-3-hydroxy-N-phenylbutanamide
• Synonyms: (R)-3-hydroxy-N-phenylbutanamide
• CAS NO: 124095-27-8
• Molecular Weight: 179.219
• Mol File: 124095-27-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (R)-3-hydroxy-N-phenylbutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-hydroxy-N-phenylbutanamide(124095-27-8)
• EPA Substance Registry System: (R)-3-hydroxy-N-phenylbutanamide(124095-27-8)

Safety Data

• Hazardous Substances Data: 124095-27-8(Hazardous Substances Data)

Upstream product

• 17645-30-6 (E)-crotonanilide 
• 103-71-9 phenyl isocyanate 
• 75-07-0 acetaldehyde 
• 31729-70-1 bis(iodozinc)methane 
• 1954-91-2 3-hydroxy-N-phenylbutansaeureamid 
• 98-88-4 benzoyl chloride 
• 102-01-2 N-phenylacetoacetamide 

Relevant articles and documents

Ru-SYNPHOS and Ru-DIFLUORPHOS: Highly efficient catalysts for practical preparation of β-hydroxy amides

Ru-SYNPHOS and Ru-DIFLUORPHOS catalysts were efficiently used for the synthesis of a wide variety of chiral β-hydroxy amides via asymmetric hydrogenation of the corresponding β-keto amides. Georg Thieme Verlag Stuttgart.

Preparation of the zinc enolate equivalent of amides by zinciomethylation of isocyanates: Catalytic asymmetric Reformatsky-type reaction

Bis(iodozincio)methane [CH2(ZnI)2] transforms isocyanates (R-N=C=O) into the enolate equivalent of amides via zinciomethylation. The reactivity of the enolate equivalent as a nucleophile toward aldehydes depends on the R group of the

Catalytic asymmetric aldol-type reaction of zinc enolate equivalent of amides

Treatment of phenyl isocyanate with bis(iodozincio)methane gave a zinciomethylenated product, which acts as an amide-enoate equivalent. It did not react with an aldehyde efficiently, but gave the corresponding adduct in good yield in the presence of an aminoalcohol. Use of a catalytic amount of chiral aminoalcohol led the process to the catalytic asymmetric Aldol-type reaction.