124257-25-6

Basic information

• Product Name: 4-amino-N-<(4-benzyl-3,4,5,6-tetrahydro-2H-1,4-thiazin-2-yl)methyl>-5-chloro-2-ethoxybenzamide
• Synonyms: 4-amino-N-<(4-benzyl-3,4,5,6-tetrahydro-2H-1,4-thiazin-2-yl)methyl>-5-chloro-2-ethoxybenzamide
• CAS NO: 124257-25-6
• Molecular Weight: 419.975
• Mol File: 124257-25-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-amino-N-<(4-benzyl-3,4,5,6-tetrahydro-2H-1,4-thiazin-2-yl)methyl>-5-chloro-2-ethoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-N-<(4-benzyl-3,4,5,6-tetrahydro-2H-1,4-thiazin-2-yl)methyl>-5-chloro-2-ethoxybenzamide(124257-25-6)
• EPA Substance Registry System: 4-amino-N-<(4-benzyl-3,4,5,6-tetrahydro-2H-1,4-thiazin-2-yl)methyl>-5-chloro-2-ethoxybenzamide(124257-25-6)

Safety Data

• Hazardous Substances Data: 124257-25-6(Hazardous Substances Data)

Upstream product

• 124257-61-0 4-benzyl-2-(azidomethyl)-3,4,5,6-tetrahydro-2H-1,4-thiazine 
• 124257-60-9 N-(4-benzyl-3,4,5,6-tetrahydro-2H-1,4-thiazin-2-yl)methylacetamide 
• 124257-57-4 ethyl 4-benzyl-5,6-dihydro-4H-1,4-thiazine-2-carboxylate 
• 124257-58-5 4-benzyl-3,4,5,6-tetrahydro-2H-1,4-thiazin-2-ylmethanol 
• 124257-59-6 4-benzyl-2-(chloromethyl)-3,4,5,6-tetrahydro-2H-1,4-thiazine 
• 101417-21-4 ethyl 5,6-dihydro-4H-1,4-thiazine-2-carboxylate 
• 100-39-0 benzyl bromide 
• 108282-38-8 4-amino-5-chloro-2-ethoxybenzoic acid 
• 170701-95-8 2-(aminomethyl)-4-benzyltetrahydro-4H-1,4-thiazine 

Relevant articles and documents

Synthesis and structure-activity relationships of 4-amino-5-chloro-2- ethoxybenzamides with six- and seven-membered heteroalicycles as potential gastroprokinetic agents

A new series of 4-amino-5-chloro-2-ethoxybenzamides 3b-f and 5-8 bearing six- and seven-membered heteroalicycles was prepared and evaluated for gastroprokinetic activity. Compounds 3b-e, derived by replacement of the morpholine oxygen of 4-amino-N-[(4-benzyl-2-morpholinyl)methyl]-5-chloro-2- ethoxybenzamide (3a) with other atoms (sulfur, nitrogen and carbon), generally exhibited a potent gastric emptying activity. N-(4-Benzyl-3- morpholinyl)methylbenzamide (5a) and its analogues 5b-e had weaker activity. However, N-(4-benzyl-3-morpholinyl)ethylbenzamide 8 was as potent as 3a. Benzamides 6a-e, having seven-membered heteroalicycles, showed fairly potent activity. Molecular superimpositions of 5a, 6a and 8 upon 3a using computer graphics suggested that the direction of the N-benzyl group greatly influences the gastric emptying activity, whereas the location of the alicyclic nitrogen is less critical.