124276-57-9

Basic information

• Product Name: 1-(3,4-DICHLOROPHENYL)CYCLOPROPANECARBONITRILE
• Synonyms: 1-(3,4-DICHLOROPHENYL)CYCLOPROPANECARBONITRILE;UKRORGSYN-BB BBV-5128505
• CAS NO: 124276-57-9
• Molecular Formula: C₁₀H₇Cl₂N
• Molecular Weight: 212.08
• Mol File: 124276-57-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 344.115°C at 760 mmHg
• Flash Point: 153.979°C
• Appearance: /
• Density: 1.381g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 1-(3,4-DICHLOROPHENYL)CYCLOPROPANECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-DICHLOROPHENYL)CYCLOPROPANECARBONITRILE(124276-57-9)
• EPA Substance Registry System: 1-(3,4-DICHLOROPHENYL)CYCLOPROPANECARBONITRILE(124276-57-9)

Safety Data

• Hazardous Substances Data: 124276-57-9(Hazardous Substances Data)

Usage

General Description

1-(3,4-Dichlorophenyl)cyclopropanecarbonitrile is a chemical compound with the molecular formula C10H6Cl2N. It is a nitrile derivative with a cyclopropane ring and two chlorophenyl groups. 1-(3,4-DICHLOROPHENYL)CYCLOPROPANECARBONITRILE is used in the synthesis of pharmaceutical and agricultural products as a building block. It has potential applications in the development of new drugs and agrochemicals, as well as in the study of chemical reactions and mechanisms. The presence of the chlorophenyl and nitrile groups in this compound makes it a versatile intermediate for the synthesis of various organic molecules. However, as a chemical compound, it also poses potential hazards and should be handled and stored with care in a controlled environment.

InChI:InChI=1/C10H7Cl2N/c11-8-2-1-7(5-9(8)12)10(6-13)3-4-10/h1-2,5H,3-4H2

Upstream product

• 107-04-0 1-Bromo-2-chloroethane 
• 3218-49-3 3,4-dichloro-benzeneacetonitrile 
• 82144-38-5 ethyl cyano(3,4-dichlorophenyl)acetate 
• 96-49-1 [1,3]-dioxolan-2-one 
• 106-93-4 ethylene dibromide 

Downstream Products

• 1432493-03-2 [1-(3,4-dichlorophenyl)cyclopropyl](pyridin-2-yl)methanone 
• 1358804-08-6 (S)-[1-(3,4-dichlorophenyl)cyclopropyl](pyridin-2-yl)methanol 
• 135522-12-2 (+/-)-N-methyl-N--1-(3',4'-dichlorophenyl)-cyclopropanecarboxylic amide 
• 437650-07-2 1-(3,4-Dichloro-phenyl)-cyclopropanecarbonyl chloride 
• 342386-78-1 1-(3,4-dichlorophenyl)cyclopropanecarboxylic acid 

Relevant articles and documents

Chiral Bidentate Boryl Ligand Enabled Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclopropanes

We herein report an Ir-catalyzed enantioselective C(sp3)-H borylation of cyclopropanecarboxamides using a chiral bidentate boryl ligand for the first time. A variety of substrates with α-quaternary carbon centers could be compatible in this reaction to provide β-borylated products with good to excellent enantioselectivities. We have also demonstrated that the borylated products can be used as versatile precursors engaging in stereospecific transformations of C-B bonds, including the synthesis of a bioactive compound Levomilnacipran.

Efficient cyclopropanation of active methylene compounds. A serendipitous discovery

Cyclopropanation of active methylene compounds has been achieved in good yields with ethylene carbonate as the cyclopropanating agent in the presence of a simple base.

N-Methyl-N--1-phenylcyclopropanecarboxylic amides - analogs of U50488 with much reduced opiate affinity and loss of κ-selectivity

(+/-)-N-methyl-N--1-phenylcyclopropanecarboxylic amide (1) and its dichloro analog (2) were synthesized.Compounds 1 and 2 are related to the κ-selective opiate U-50488 in that the benzylic methylene moiety in U-50488 has been replaced by a cyclopropane ring.As compared to U-50488, a 600-fold reduction in kappa-affinity was observed with these 2 compounds; while the reduction in μ-affinity was less than 2-fold.Unlike U-50488, 1 and 2 also show measurable δ-binding.To explain the observed anomaly, the steric interaction between the N-methyl group and the cyclopropane ring and the tendency of the cyclopropane ring to conjugate with the neighboring phenyl group, both affecting the accessible conformations of the amide side chains of 1 and 2, are cosidered important factors.