1242772-51-5Relevant articles and documents
Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR)
Tsou, Hwei-Ru,MacEwan, Gloria,Birnberg, Gary,Grosu, George,Bursavich, Matthew G.,Bard, Joel,Brooijmans, Natasja,Toral-Barza, Lourdes,Hollander, Irwin,Mansour, Tarek S.,Ayral-Kaloustian, Semiramis,Yu, Ker
scheme or table, p. 2321 - 2325 (2010/08/22)
We discovered 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR). Since phenolic OH groups pose metabolic liability, one of th
