124292-87-1

Basic information

• Product Name: ethyl 1-imino-2-isopropyloxy acetate
• Synonyms: ethyl 1-imino-2-isopropyloxy acetate
• CAS NO: 124292-87-1
• Molecular Weight: 159.185
• Mol File: 124292-87-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: ethyl 1-imino-2-isopropyloxy acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1-imino-2-isopropyloxy acetate(124292-87-1)
• EPA Substance Registry System: ethyl 1-imino-2-isopropyloxy acetate(124292-87-1)

Safety Data

• Hazardous Substances Data: 124292-87-1(Hazardous Substances Data)

Upstream product

• 67-63-0 isopropyl alcohol 
• 623-49-4 ethyl cyanoformate 
• 108-20-3 di-isopropyl ether 

Downstream Products

• 898-22-6 triethyl 1,3,5-triazine-2,4,6-tricarboxylate 
• 124292-93-9 4-Isopropoxy-2-phenyl-2-trifluoromethyl-2H-oxazol-5-one 
• 124292-86-0 2-isopropoxy-1-aza-4-oxaspiro[4.5]dec-1-en-3-one 
• 124292-97-3 4-isopropoxy-2-phenyl-1,3-oxazol-5(2H)-one 
• 26404-26-2 ethyl 2-propyl oxalate 
• 83566-38-5 diethyl 5-aminoimidazole-2,4-dicarboxylate 

Relevant articles and documents

Preparative route to 2-ethoxycarbonylimidazole-4-phosphonate and diethyl imidazole-2,4-dicarboxylate

Practical synthesis of 2-ethoxycarbonylimidazole-4-phosphonate (1a) and diethyl imidazole-2,4-dicarboxylate (1b) are described.

Method for synthesizing intermediate product thiazolecarboxylic acid chemical intermediate

The invention relates to a method for synthesizing an intermediate product thiazolecarboxylic acid chemical intermediate, comprising the following steps: (a) mixing ethyl cyanoformate, isopropyl etherand isopropanol, and cooling to minus 20- minus 5 DEG C under the inert gas protection; (b) stirring and mixing water, sodium bicarbonate, ice and methyl tert-butyl ether, adding the intermediate, keeping the water temperature below 0 DEG C and keeping the pH to be weakly alkaline so as to free the intermediate; (c) adding the compound 2 into ethanol, cooling under the inert gas protection with an ice bath, and adding ammonium chloride for a reaction; (d) dissolving the compound 3 in dichloromethane and adding perchloromethyl mercaptan at minus 10- minus 5 DEG C. The method of the invention is conducive to industrial batch production of 5-ethoxy-1,2,4-thiadiazole-3-carboxylic acid.

Synthesis of 4-Alkoxy-1,3-oxazol-5(2H)-ones, Precursors of 1-Alkoxy-Substituted Nitrile Ylides

4-Alkoxy-1,3-oxazol-5(2H)-ones of type 4 and 7 were synthesized by two different methods: oxidation of the 4-(phenylthio)-1,3-oxazol-5(2H)-one 2a with m-chloroperbenzoic acid in the presence of an alcohol gave the corresponding 4-alkoxy derivatives 4, presumably via nucleophilic substitution of an intermediate sulfoxide (Scheme 2).The second approach is the BF3-catalyzed condensation of imino-acetates of type 6 and ketones (Scheme 3).The yields of this more straightforward method were modest due to the competitive formation of 1,3,5-triazine tricarboxylate 8.At 155 deg C, 1,3-oxazol-5(2H)-one 7b underwent decarboxylation leading to an alkoxy-substituted nitrile ylide which was trapped in a 1,3-dipolar cycloaddition by trifluoro-acetophenone to give the dihydro-oxazoles cis- and trans-9 (Scheme 4).In the absence of a dipolarophile, 1,5-dipolar cyclization of the intermediate nitrile ylide yielded isoindole derivatives 10 (Schemes 4 and 5).