1242934-32-2

Basic information

• Product Name: (2S,4S)-Fmoc-4-trifluoromethyl-pyrrolidine-2-carboxylic acid
• Synonyms: (2S,4S)-Fmoc-4-trifluoromethyl-pyrrolidine-2-carboxylic acid
• CAS NO: 1242934-32-2
• Molecular Formula: C21H18F3NO4
• Molecular Weight: 405.3671296
• Mol File: 1242934-32-2.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 539.5±50.0 °C(Predicted)
• Appearance: /
• Density: 1.412±0.06 g/cm3(Predicted)
• PKA: 3.60±0.40(Predicted)
• CAS DataBase Reference: (2S,4S)-Fmoc-4-trifluoromethyl-pyrrolidine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4S)-Fmoc-4-trifluoromethyl-pyrrolidine-2-carboxylic acid(1242934-32-2)
• EPA Substance Registry System: (2S,4S)-Fmoc-4-trifluoromethyl-pyrrolidine-2-carboxylic acid(1242934-32-2)

Safety Data

• Hazardous Substances Data: 1242934-32-2(Hazardous Substances Data)

Usage

Description

(2S,4S)-Fmoc-4-trifluoromethyl-pyrrolidine-2-carboxylic acid is a chemical compound characterized by a pyrrolidine ring with a trifluoromethyl group and a carboxylic acid functional group. It features an Fmoc (9-fluorenylmethyloxycarbonyl) protecting group for the amino group of amino acids during peptide synthesis. (2S,4S)-Fmoc-4-trifluoromethyl-pyrrolidine-2-carboxylic acid's (2S,4S) stereochemistry is crucial for its biological activity and interactions in chemical reactions. The trifluoromethyl group enhances its lipophilicity and metabolic stability, making it a valuable component in pharmaceutical development.

Uses

Used in Pharmaceutical Industry:
(2S,4S)-Fmoc-4-trifluoromethyl-pyrrolidine-2-carboxylic acid is used as a building block for the synthesis of complex pharmaceuticals. Its unique structure and properties contribute to the development of new drugs with improved efficacy and stability.
Used in Peptide Synthesis:
In the field of peptide synthesis, (2S,4S)-Fmoc-4-trifluoromethyl-pyrrolidine-2-carboxylic acid serves as a key component, providing a protected amino acid building block that facilitates the assembly of peptide sequences with greater ease and precision.
Used in Drug Design and Discovery:
(2S,4S)-Fmoc-4-trifluoromethyl-pyrrolidine-2-carboxylic acid is utilized in drug design and discovery due to its beneficial properties, such as increased lipophilicity and metabolic stability, which can lead to the creation of more effective and longer-lasting medications.