124391-60-2

Basic information

• Product Name: 4-Nitro-2-phenylbenzoic acid
• Synonyms: 4-Nitro-2-phenylbenzoic acid;5-Nitro-biphenyl-2-carboxylic acid;5-Nitro-2-biphenylcarboxylic acid
• CAS NO: 124391-60-2
• Molecular Formula: C₁₃H₉NO₄
• Molecular Weight: 243.21486
• Mol File: 124391-60-2.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Nitro-2-phenylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitro-2-phenylbenzoic acid(124391-60-2)
• EPA Substance Registry System: 4-Nitro-2-phenylbenzoic acid(124391-60-2)

Safety Data

• Hazardous Substances Data: 124391-60-2(Hazardous Substances Data)

Usage

General Description

4-Nitro-2-phenylbenzoic acid is a chemical compound with the molecular formula C13H9NO4. It is a nitro derivative of 2-phenylbenzoic acid and consists of a nitro group and a phenyl ring attached to a benzoic acid molecule. 4-Nitro-2-phenylbenzoic acid is commonly used in organic synthesis and pharmaceutical research as a building block for more complex molecules. It has been studied for its potential anti-inflammatory and antitumor properties. Additionally, it has been used in the development of new materials and as a reagent in chemical reactions. Overall, 4-Nitro-2-phenylbenzoic acid has various applications in the fields of chemistry, medicine, and materials science.

Upstream product

• 6326-42-7 2-iodo-4-nitrobenzoic acid methyl ester 
• 591-50-4 iodobenzene 
• 62-23-7 4-nitro-benzoic acid 
• 124391-54-4 2-(bromomethyl)-5-nitro-1,1'-biphenyl 
• 98-80-6 phenylboronic acid 
• 7745-93-9 2-bromo-4-nitrotoluene 
• 64-19-7 acetic acid 
• 13480-38-1 4-Nitro-2-phenyltoluene 
• 124391-58-8 2-Formyl-5-nitrobiphenyl 

Downstream Products

• 191101-08-3 [4-(3-pyridylmethylamino)-2-phenylbenzoyl]homoserine lactone 
• 489409-89-4 5-nitro-biphenyl-2-carboxylic acid cyclohexyl ester 
• 58084-75-6 9-hydroxy-3-nitrofluorene 
• 180977-36-0 (S)-2-{[5-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-biphenyl-2-carbonyl]-amino}-4-methyl-pentanoic acid methyl ester 
• 205590-50-7 (2S,3S)-2-{[5-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-biphenyl-2-carbonyl]-amino}-3-methyl-pentanoic acid methyl ester 
• 205590-51-8 (S)-2-{[5-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-biphenyl-2-carbonyl]-amino}-hexanoic acid methyl ester 
• 655234-96-1 2-({5-[(3-biphenyl-4-ylmethyl-3H-imidazol-4-ylmethyl)-amino]-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid methyl ester 
• 655235-64-6 4-[N-(1-(4-phenyl)benzyl-1H-imidazol-4-yl)methylamino]-2-phenylbenzoylmethionine methyl ester 
• 880106-49-0 4-[N-(1-(1-naphthyl)methyl-1H-imidazol-4-yl)methylamino]-2-phenylbenzoylmethionine methyl ester 
• 655235-66-8 4-[N-(1-cyclohexylmethyl-1H-imidazol-4-yl)methylamino]-2-phenylbenzoylmethionine methyl ester 
• 655235-70-4 4-[N-(1-cyclohexylmethyl-1H-imidazol-5-yl)methylamino]-2-phenylbenzoylmethionine methyl ester 
• 655234-30-3 2-[(5-{[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid methyl ester 

Relevant articles and documents

Synthesis and radiofluorination of novel fluoren-9-one based derivatives for the imaging of α7 nicotinic acetylcholine receptor with PET

By structure–activity relationship studies on the tilorone scaffold, the ‘one armed’ substituted dibenzothiophenes and the fluoren-9-ones were identified as the most potential α7 nAChR ligands. While the suitability of dibenzothiophene derivatives as PET tracers is recognized, the potential of fluoren-9-ones is insufficiently investigated. We herein report on a series of fluoren-9-one based derivatives targeting α7 nAChR with compounds 8a and 8c possessing the highest affinity and selectivity. Accordingly, with [18F]8a and [18F]8c we designed and initially evaluated the first fluoren-9-one derived α7 nAChR selective PET ligands. A future application of these radioligands is facilitated by the herein presented successful implementation of fully automated radiosynthesis.

General and practical carboxyl-group-directed remote C-H oxygenation reactions of arenes

Two methods for remote aromatic C-H oxygenation reactions, have been developed. Method1, the Cu-catalyzed oxygenation reaction, is highly efficient for cyclization of electron-neutral and electron-rich biaryl carboxylic acids into 3,4-benzocoumarins. Method2, the K2S2O 8-mediated oxygenation reaction, is more general and practical for cyclization of substrates with electron-donating and -withdrawing groups (see scheme). Copyright

N-THIAZOL-2-YL-BENZAMIDE DERIVATIVES

The invention relates to N-thiazol-2-yl-benzamide derivatives of the formula I in the description wherein the variables are as defined in the claims. The compounds are A2A-receptor ligands, such as antagonists, agonists, reverse agonists or partial agonists, and are useful in the treatment of neurological and psychiatric disorders where an A2A-receptor is implicated.