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124473-12-7

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124473-12-7 Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 124473-12-7 differently. You can refer to the following data:
1. 2-Chloromethyl-4-methoxy-3-methylpyridine is a pyridine derivative used in the preparation of anti-ulcerative agents and other pharmaceutical compounds.
2. 2-CHLOROMETHYL-4-METHOXY-3-METHYLPYRIDINE HYDROCHLORIDE is used in the preparation of anti-ulcerative agents and other pharmaceutical compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 124473-12-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,4,7 and 3 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 124473-12:
(8*1)+(7*2)+(6*4)+(5*4)+(4*7)+(3*3)+(2*1)+(1*2)=107
107 % 10 = 7
So 124473-12-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H10ClNO/c1-6-7(5-9)10-4-3-8(6)11-2/h3-4H,5H2,1-2H3

124473-12-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Chloromethyl-4-methoxy-3-methylpyridine

1.2 Other means of identification

Product number -
Other names 2-CHLOROMETHYL-4-METHOXY-3-METHYLPYRIDINE HYDROCHLORIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:124473-12-7 SDS

124473-12-7Synthetic route

2-hydroxymethyl-4-methoxy-3-methylpyridine
86604-77-5

2-hydroxymethyl-4-methoxy-3-methylpyridine

2-chloromethyl-3-methyl-4-methoxypyridine
124473-12-7

2-chloromethyl-3-methyl-4-methoxypyridine

Conditions
ConditionsYield
With thionyl chloride In dichloromethane at 25℃; for 2h;
With thionyl chloride In dichloromethane at 0℃;
2,3-dimethyl-4-nitropyridine N-oxide
37699-43-7

2,3-dimethyl-4-nitropyridine N-oxide

2-chloromethyl-3-methyl-4-methoxypyridine
124473-12-7

2-chloromethyl-3-methyl-4-methoxypyridine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 82 percent / K2CO3 / 20 h / Heating
2: 110 °C
3: 10percent aq. HCl / 1.5 h / 90 °C
4: SOCl2 / CH2Cl2 / 0 °C
View Scheme
4-methoxy-2,3-dimethylpyridine 1-oxide
102625-96-7

4-methoxy-2,3-dimethylpyridine 1-oxide

2-chloromethyl-3-methyl-4-methoxypyridine
124473-12-7

2-chloromethyl-3-methyl-4-methoxypyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 110 °C
2: 10percent aq. HCl / 1.5 h / 90 °C
3: SOCl2 / CH2Cl2 / 0 °C
View Scheme
Multi-step reaction with 3 steps
1: AcOH / 120 °C
2: 2N aq. NaOH / methanol / 2 h / 25 °C
3: SOCl2 / CH2Cl2 / 2 h / 25 °C
View Scheme
2-acetoxymethyl-4-methoxy-3-methylpyridine
102625-98-9

2-acetoxymethyl-4-methoxy-3-methylpyridine

2-chloromethyl-3-methyl-4-methoxypyridine
124473-12-7

2-chloromethyl-3-methyl-4-methoxypyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 10percent aq. HCl / 1.5 h / 90 °C
2: SOCl2 / CH2Cl2 / 0 °C
View Scheme
Multi-step reaction with 2 steps
1: 2N aq. NaOH / methanol / 2 h / 25 °C
2: SOCl2 / CH2Cl2 / 2 h / 25 °C
View Scheme
2-mercaptothieno<3,4-d>imidazole
90070-09-0

2-mercaptothieno<3,4-d>imidazole

2-chloromethyl-3-methyl-4-methoxypyridine
124473-12-7

2-chloromethyl-3-methyl-4-methoxypyridine

2-(4-Methoxy-3-methyl-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole
111371-73-4

2-(4-Methoxy-3-methyl-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole

Conditions
ConditionsYield
In ethanol Heating;59%
2-chloromethyl-3-methyl-4-methoxypyridine
124473-12-7

2-chloromethyl-3-methyl-4-methoxypyridine

Benzimidazol-2-thiol
134469-07-1

Benzimidazol-2-thiol

2-[[(4-methoxy-3-methylpyridin-2-yl)methyl]mercapto]-1H-benzimidazole
102804-82-0

2-[[(4-methoxy-3-methylpyridin-2-yl)methyl]mercapto]-1H-benzimidazole

Conditions
ConditionsYield
With sodium hydroxide In ethanol Heating; Yield given;
2-chloromethyl-3-methyl-4-methoxypyridine
124473-12-7

2-chloromethyl-3-methyl-4-methoxypyridine

2-(4-methoxy-3-methyl-2-picolyl-sulfinyl)-1H-thieno[3,4-d]imidazole
111371-27-8

2-(4-methoxy-3-methyl-2-picolyl-sulfinyl)-1H-thieno[3,4-d]imidazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 59 percent / ethanol / Heating
2: 65 percent / aq. sodium bicarbonate, m-chloroperbenzoic acid / CH2Cl2 / 0.17 h / 0 °C
View Scheme
5,7-dihydro-2-mercapto-5,5,7,7-tetramethylindeno[5,6-d]-imidazol-6(1H)-one
81864-06-4

5,7-dihydro-2-mercapto-5,5,7,7-tetramethylindeno[5,6-d]-imidazol-6(1H)-one

2-chloromethyl-3-methyl-4-methoxypyridine
124473-12-7

2-chloromethyl-3-methyl-4-methoxypyridine

5,7-dihydro-2-[[(4-methoxy-3-methyl-pyridin-2-yl)methyl]thio]-5,5,7,7-tetramethylindeno[5,6-d]imidazol-6(1H)-one
101387-97-7

5,7-dihydro-2-[[(4-methoxy-3-methyl-pyridin-2-yl)methyl]thio]-5,5,7,7-tetramethylindeno[5,6-d]imidazol-6(1H)-one

Conditions
ConditionsYield
In acetone

124473-12-7Relevant articles and documents

Structure-activity relationship of 2-[[(2-Pyridyl)methyl]thio]-1H- benzimidazoles as anti Helicobacter pylori agents in vitro and evaluation of their in vivo efficacy

Kühler, Thomas C.,Swanson, Marianne,Shcherbuchin, Vladimir,Larsson, H?kan,Mellg?rd, Bj?rn,Sj?str?m, Jan-Eric

, p. 1777 - 1788 (2007/10/03)

A relationship between the structure of 21 2-[[(2-pyridyl)methyl]thio]- 1H-benzimidazoles (6) and their anti Helicobacter pylori activity expressed as minimum bactericidal concentration (MBC) values is described. Observed MBCs ranged from 256 to 1 μg/mL. The structure - activity relationship (SAR) showed that larger and more lipophilic compounds, especially compounds with such substituents in the 4-position of the pyridyl moiety, generally had lower MBC values. Four new compounds 'that were predicted to be potent by the established SAR model were synthesized and tested. One such compound, i.e., 2-[[(4-[(cyclopropylmethyl)oxy]3-methyl-2-pyridyl)methyl]thio]-1H- benzimidazole (18), was tested for in vivo efficacy in a mouse Helicobacter felis model (125 μmol/kg bid given orally for 4 days, n = 4). Unfortunately, antibacterial activity could not be clearly demonstrated in this model. Instead a potent acid secretion inhibition was observed. This finding was attributed to the methylthio compound being oxidized to the corresponding methyl sulfinyl derivative, i.e., a proton pump inhibitor, in vivo. Although the antibacterial activity had the potential of decreasing H. felis cell counts in vivo the proton pump inhibitory effect became dominant and actually promoted H. felis cell growth. Hence, we conclude that the antibacterial utility of the 2-[[(2-pyridyl)methyl]thio]1H-benzimidazoles (6) as a compound class is compromised by their propensity to become proton pump inhibitors upon metabolic oxidation in vivo.

4(3H)-quinazolinone derivatives and pharmaceutical compositions

-

, (2008/06/13)

4(3H)-Quinazolinone derivatives of formula (I) are provided. STR1 wherein R1 is a hydrogen atom, a C1 -C6 alkyl group, an aryl group, a substituted aryl group, or an aralkyl group; R2 is a C1 -C6 alkylamino group, a phenyl group, a substituted phenyl group, or a 5- or 6-membered heterocyclic group containing one or more N, O or S as a hetero atom or atoms, said heterocyclic group optionally being substituted or fused with a benzene ring; n is 1 or 2; or R2 represents a geranyl group or a dipyridylmethyl group together with the group --(CH2)n --; and X is a hydrogen atom, a C1 -C6 alkyl group or a halogen atom, and pharmaceutically acceptable acid addition salts thereof. They are useful as antiulcer agents.

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